Anxiogenic and stress-inducingeffects of peripherally administeredacetaldehyde in mice: Similarities with the disulfiram–ethanol reaction
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Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/8636
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http://dx.doi.org/10.1016/j.pbb.2011.10.002 |
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Title
Anxiogenic and stress-inducingeffects of peripherally administeredacetaldehyde in mice: Similarities with the disulfiram–ethanol reactionDate
2012Publisher
ElsevierISSN
0091-3057Bibliographic citation
Pharmacology Biochemistry and Behavior (Jan. 2012) vol. 100, no. 3, p. 404-412Type
info:eu-repo/semantics/articlePublisher version
http://www.sciencedirect.com/science/article/pii/S0091305711003248Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
Peripheral accumulation of acetaldehyde, the first metabolite of ethanol, produces autonomic responses in humans called “flushing”. The aversive characteristics of flushing observed in some populations with an isoform ... [+]
Peripheral accumulation of acetaldehyde, the first metabolite of ethanol, produces autonomic responses in humans called “flushing”. The aversive characteristics of flushing observed in some populations with an isoform of aldehyde dehydrogenase (ALDH2) less active, are the basis for treating alcoholics with disulfiram, an ALDH inhibitor. Although ethanol and centrally formed acetaldehyde have anxiolytic effects, peripheral accumulation of acetaldehyde may be aversive in part because it is anxiogenic. [-]
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© 2012 Elsevier Inc. All rights reserved
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- PSB_Articles [1321]