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Anxiogenic and stress-inducingeffects of peripherally administeredacetaldehyde in mice: Similarities with the disulfiram–ethanol reaction
dc.contributor.author | Escrig, Miguel A. | |
dc.contributor.author | Pardo Andrés, Marta | |
dc.contributor.author | González Aragón, Carlos Manuel | |
dc.contributor.author | Correa, Merce | |
dc.date.accessioned | 2012-09-12T10:22:54Z | |
dc.date.available | 2012-09-12T10:22:54Z | |
dc.date.issued | 2012 | |
dc.identifier.citation | Pharmacology Biochemistry and Behavior (Jan. 2012) vol. 100, no. 3, p. 404-412 | |
dc.identifier.issn | 0091-3057 | |
dc.identifier.uri | http://hdl.handle.net/10234/46888 | |
dc.description.abstract | Peripheral accumulation of acetaldehyde, the first metabolite of ethanol, produces autonomic responses in humans called “flushing”. The aversive characteristics of flushing observed in some populations with an isoform of aldehyde dehydrogenase (ALDH2) less active, are the basis for treating alcoholics with disulfiram, an ALDH inhibitor. Although ethanol and centrally formed acetaldehyde have anxiolytic effects, peripheral accumulation of acetaldehyde may be aversive in part because it is anxiogenic. | ca_CA |
dc.format.extent | 9 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language | eng | ca_CA |
dc.language.iso | cat | ca_CA |
dc.publisher | Elsevier | ca_CA |
dc.rights | © 2012 Elsevier Inc. All rights reserved | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | * |
dc.subject | Acetaldehyde | ca_CA |
dc.subject | Acetate | ca_CA |
dc.subject | Disulfiram | ca_CA |
dc.subject | Ethanol | ca_CA |
dc.subject | Dark–light box | ca_CA |
dc.subject | Elevated plus maze | ca_CA |
dc.title | Anxiogenic and stress-inducingeffects of peripherally administeredacetaldehyde in mice: Similarities with the disulfiram–ethanol reaction | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | http://dx.doi.org/10.1016/j.pbb.2011.10.002 | |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | ca_CA |
dc.relation.publisherVersion | http://www.sciencedirect.com/science/article/pii/S0091305711003248 | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
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