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IFN-c signaling, with the synergistic contribution of TNF-a, mediates cell specific microglial and astroglial activation in experimental models of Parkinson’s disease
(Nature Publishing Group, 2011)
To through light on the mechanisms underlying the stimulation and persistence of glial cell activation in Parkinsonism, we
investigate the function of IFN-c and TNF-a in experimental models of Parkinson’s disease and ...
Nigral degeneration correlates with persistent activation of cerebellar Purkinje cells in MPTP-treated monkeys
(Universidad de Murcia, 2012)
In the present work we analyze the
cerebellum of chronic parkinsonian monkeys in order to
clarify whether chronic mesencephalic depletion is
associated with long term activation of the cerebellar
neurons in chronic ...
Effects of pharmacological agents, sleep deprivation, hypoxia and transcranial magnetic stimulation on electroencephalographic rhythms in rodents: Towards translational challenge models for drug discovery in Alzheimer’s disease
(Elsevier, 2013)
Different kinds of challenge can alter spontaneous ongoing electroencephalographic (EEG) rhythms in animal models, thus providing paradigms to evaluate treatment effects in drug discovery. The effects of challenges represented ...
The perspective of patients and health professionals on the prioritization of assisted reproductive techniques : the PRIOFER study
(Taylor and Francis GroupDove Press, 2023-10-30)
-Purpose : To determine the perspective of patients and professionals in Assisted Reproduction Units (ARU) on the importance of assisted reproductive techniques (ART) compared to other elective procedures, to highlight the ...
Evaluation of prophylaxis in primary prevention with acetylsalicylic acid in people with diabetes: A scoping review
(Sociedad Española de Médicos de Atención PrimariaElsevier, 2022-02)
The efficacy and safety of acetylsalicylic acid (ASA) prophylaxis for the primary
prevention of atherosclerotic cardiovascular disease (ACVD) remain controversial in people with
diabetes (DM) without ACVD, because the ...
The rostromedial tegmental nucleus RMTg is not a critical site for ethanol-induced motor activation in rats
(Springer Nature, 2023-07-20)
-Rationale :
Opioid drugs indirectly activate dopamine (DA) neurons in the ventral tegmental area (VTA) through a disinhibition mechanism mediated by mu opioid receptors (MORs) present both on the GABA projection neurons ...
Characterizing diagnostic inertia in arterial hypertension with a gender perspective in primary care
(Guido Iaccarino, University of Naples Federico II, Italy, 2022)
Background and Objectives: Substantial evidence shows that diagnostic inertia leads to failure to achieve screening and diagnosis objectives for arterial hypertension (AHT). In addition, different studies suggest that the ...
Persistent phagocytic characteristics of microglia in the substantia nigra of long-term Parkinsonian macaques
(Elsevier, 2013)
Patients with Parkinson's disease show persistent microglial activation in the areas of the brain where the degeneration of dopaminergic neurons takes place. The reason for maintaining this activated state is still unknown, ...
Exercise training response according to baseline ferrokinetics in heart failure with preserved ejection fraction: A substudy of the TRAINING-HF trial
(Wiley Open Access, 2024-01-15)
Background Iron deficiency (ID) is associated with impaired functional capacity in patients with heart failure (HF),
even in those with preserved ejection fraction (HFpEF). This study aimed to evaluate the effect of ...
Targeting Alzheimer's disease with multimodal polypeptide-based nanoconjugates
(AAAS (American Association for the Advancement of Science), 2021-03-26)
Alzheimer’s disease (AD), the most prevalent form of dementia, remains incurable mainly due to our failings in the search for effective pharmacological strategies. Here, we describe the development of targeted multimodal ...