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The effects of heavy metal exposure on brain and gut microbiota: A systematic review of animal studies
Elsevier (2024-03-08)The gut-brain axis is a crucial interface between the central nervous system and the gut microbiota. Recent evidence shows that exposure to environmental contaminants, such as heavy metals, can cause dysbiosis in gut ... -
The extent of aortic lymphadenectomy in locally advanced cervical cancer impacts on survival
Asian Society of Gynecologic Oncology (2021-01-06)Objective: The prognostic impact of surgical paraaortic staging remains unclear in patients with locally advanced cervical cancer (LACC). The objective of our study was to evaluate the results of the surgical technique ... -
The impact of patient support programs in Europe: a systematic literature review
Springer Nature (2022-06-21)Background and Objective : Patient support programs aim to provide solutions beyond the medication itself, by enhancing treatment adherence, improving clinical outcomes, elevating patient experience, and/or increasing ... -
The Interplay between Natural Selection and Susceptibility to Melanoma on Allele 374F of SLC45A2 Gene in a South European Population
Public Library of Science (2014)We aimed to study the selective pressures interacting on SLC45A2 to investigate the interplay between selection and susceptibility to disease. Thus, we enrolled 500 volunteers from a geographically limited population ... -
The JAK2 pathway is activated in idiopathic pulmonary fibrosis
BioMed Central (2018)Background: Idiopathic pulmonary fibrosis (IPF) is the most rapidly progressive and fatal fibrotic disorder, with no curative therapies. The signal transducer and activator of transcription 3 (STAT3) protein is activated ... -
The maternal hormone in the male brain: Sexually dimorphic distribution of prolactin signalling in the mouse brain
Public Library of Science (2018)Research of the central actions of prolactin is highly focused on females, but this hormone has also documented roles in male physiology and behaviour. Here, we provide the first description of the pattern of prolactin-derived ... -
The pallial amygdala of amniote vertebrates: evolution of the concept, evolution of the structure
Elsevier (2002-02)Embryological studies indicate that the amygdala includes pallial structures, namely the cortical amygdala (olfactory and vomeronasal) and the basolateral complex deep to it. In squamate reptiles, the cortical amygdala ... -
The perspective of patients and health professionals on the prioritization of assisted reproductive techniques : the PRIOFER study
Taylor and Francis Group (2023-10-30)-Purpose : To determine the perspective of patients and professionals in Assisted Reproduction Units (ARU) on the importance of assisted reproductive techniques (ART) compared to other elective procedures, to highlight the ... -
The purine analogues abacavir and didanosine increase acetaminophen-induced hepatotoxicity by enhancing mitochondrial dysfunction
Oxford University Press (2016-01-07)Background NRTIs are essential components of HIV therapy with well-documented, long-term mitochondrial toxicity in hepatic cells, but whose acute effects on mitochondria are unclear. As acetaminophen-induced hepatotoxicity ... -
The role of mucin 1 in respiratory diseases
European Respiratory Society (2021-03-31)Recent evidence has demonstrated that mucin 1 (MUC1) is involved in many pathological processes that occur in the lung. MUC1 is a transmembrane protein mainly expressed by epithelial and hematopoietic cells. It has a ... -
The role of parental social class, education and unemployment on child cognitive development
Sociedad Española de Salud Pública y Administración Sanitaria (2020-01)Objective: Assessing the association between socioeconomic gradient and cognitive development among children of a Spanish birth cohort aged 5-6 years from a gender perspective. Method: Cognitive development was assessed ... -
The role of the cerebellum in drug-cue associative memory: functional interactions with the medial prefrontal cortex
John Wiley (2018-10-02)Drug-induced Pavlovian memories are thought to be crucial for drug addiction because they guide behaviour towards environments with drug availability. Drug-related memory depends on persistent changes in dopamine-glutamate ... -
The rostromedial tegmental nucleus RMTg is not a critical site for ethanol-induced motor activation in rats
Springer Nature (2023-07-20)-Rationale : Opioid drugs indirectly activate dopamine (DA) neurons in the ventral tegmental area (VTA) through a disinhibition mechanism mediated by mu opioid receptors (MORs) present both on the GABA projection neurons ... -
The TrkB agonist 7,8-dihydroxyflavone changes the structural dynamics of neocortical pyramidal neurons and improves object recognition in mice
Springer Verlag (2018-06)BDNF and its receptor TrkB have important roles in neurodevelopment, neural plasticity, learning, and memory. Alterations in TrkB expression have been described in different CNS disorders. Therefore, drugs interacting with ... -
The Use of Barbed Suture for Vaginal Cuff Closure in Total Laparoscopic Hysterectomy
MedCrave (2015-12)Objective: The aim of this work is to evaluate the safety and efficacy of the barbed unidirectional suture in a total laparoscopic hysterectomy. Materials and Methods: A retrospective and descriptive study was conducted, ... -
The use of lower or higher than recommended doses of folic acid supplements during pregnancy is associated with child attentional dysfunction at 4-5 years of age in the INMA Project
MDPI (2021-01-23)We assessed the association between the use of lower- and higher-than-recommended doses of folic acid supplements (FAs) during pregnancy and attentional function in boys and girls at age of 4-5. We analyzed data from 1329 ... -
Thyrotoxicosis following SARS-COV-2 vaccination: a case series and discussion
Springer (2022-01-11)Aim To describe a case series of thyrotoxicosis likely triggered by SARS-CoV-2 vaccination and to warn physicians about this potential correlation. To report clinical, laboratory and imaging fndings and provide further ... -
Transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission
Nature Research (2020)n rodent models of type 2 diabetes (T2D), sustained remission of hyperglycemia can be induced by a single intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1), and the mediobasal hypothalamus (MBH) ... -
Trastorno por déficit de atención con hiperactividad y trastorno bipolar en gemelas dicigóticas. A propósito de un caso
Elsevier España (2008-03)Desde que Wozniak et al describieran una elevada incidencia de trastorno bipolar (16%) entre los niños y adolescentes diagnosticados de trastorno por déficit de atención con hiperactividad (TDAH) ha existido un interés ...