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Mostrando ítems 329-348 de 657

    • closedAccess   Iron deficiency and short-term adverse events in patients with decompensated heart failure 

      Palau, Patricia; Llàcer, Pau; Domínguez Mafé, Eloy; Tormo, Juan Pablo; Zakarne, Rim; Mollar, Anna; Martínez, Ana; Miñana, Gema; Santas, Enrique; Almenar-Bonet, Luis; Fácila, Lorenzo; De la Espriella, Rafael; Núñez, Eduardo; Manzano, Luis; Bayes-Genis, Antoni; Núñez, Julio Springer (2021-03-15)
      Background: For patients with heart failure (HF), iron deficiency (ID) is a common therapeutic target. However, little is known about the utility of transferrin saturation (TSAT) or serum ferritin for risk stratification ...

    • openAccess   IRS-2 deficiency impairs NMDA receptor-dependent long-term potentiation 

      Sánchez-Pérez, Ana María; Martín, Eduardo D.; Trejo, José Luis; Martín Aldana, Juan Antonio; Cano Jaimez, Marife; Pons, Sebastian; Acosta Umanzor, Carlos; Menes, Lorena; White, Morris F.; Burks, Deborah J. Oxford University Press (2012-08)
      The beneficial effects of insulin and insulin-like growth factor I on cognition have been documented in humans and animal models. Conversely, obesity, hyperinsulinemia, and diabetes increase the risk for neurodegenerative ...

    • closedAccess   Is Glycemic Control Modulating Endoplasmic Reticulum Stress in Leukocytes of Type 2 Diabetic Patients? 

      Rovira Llopis, Susana; Bañuls, Celia; Apostolova, Nadezda; Morillas, Carlos; Hernández Mijares, Antonio; Rocha, Milagros; Víctor, Víctor M. Mary Ann Liebert Inc. (2014-10-06)
      Oxidative and endoplasmic reticulum (ER) stress is related to type 2 diabetes (T2D), but the influence of glycemic control on these parameters and its relationship with leukocyte-endothelial interactions is not known. In ...

    • openAccess   Is the Physician’s Behavior in Dyslipidemia Diagnosis in Accordance with Guidelines? Cross-Sectional Escarval Study 

      Palazón-Bru, Antonio; Gil-Guillén, Vicente F; Orozco Beltrán, Domingo; Pallarés-Carratalá, Vicente; Valls Roca, Francisco; Sanchis-Domenech, Carlos; Martin-Moreno, Jose M.; Redón, Josep; Navarro Pérez, Jorge; Fernández Giménez, Antonio; Pérez Navarro, Ana M.; Trillo, José L.; Usó, Ruth; Ruiz, Elías Public Library of Science (2014)
      Background: Clinical inertia has been defined as mistakes by the physician in starting or intensifying treatment when indicated. Inertia, therefore, can affect other stages in the healthcare process, like diagnosis. The ...

    • openAccess   Is There A Role for Abscisic Acid, A Proven Anti-Inflammatory Agent, in the Treatment of Ischemic Retinopathies? 

      Baliño, Pablo; Gomez-Cadenas, Aurelio; López Malo, Daniel; Romero, Francisco J.; Muriach, Maria MDPI (2019)
      Ischemic retinopathies (IRs) are the main cause of severe visual impairment and sight loss, and are characterized by loss of blood vessels, accompanied by hypoxia, and neovascularization. Actual therapies, based on ...

    • openAccess   Is There a Role of Beetroot Consumption on the Recovery of Oxidative Status and Muscle Damage in Ultra-Endurance Runners? 

      Vilar Yebra, Eva; Collado-Boira, Eladio; Guerrero, Carlos; Folch Ayora, Ana; Salas-Medina, Pablo; Hernando, Carlos; Baliño, Pablo; Muriach, Maria MDPI (2024-02)
      (1) Background: Ultra-endurance exercise involves a high physical impact, resulting in muscle damage, inflammatory response and production of free radicals that alter the body’s oxidative state. Supplementation with ...

    • closedAccess   Isolated Partial Congenital Absence of the Pericardium: A Familial Presentation 

      Palau, Patricia; Domínguez Mafé, Eloy; García González, Pilar; Gallego Peris, Jorge; Bosch, María José; Sieso, Eduardo Elsevier (2015)
      Congenital defects of the pericardium are uncommon heart abnormalities. Most of the patients are asymptomatic and are usually diagnosed incidentally. Complications are more common in partial absence than in complete absence ...

    • closedAccess   JAK2 mediates lung fibrosis, pulmonary vascular remodelling and hypertension in idiopathic pulmonary fibrosis: an experimental study 

      MILARA, JAVIER; Ballester, Beatriz; Morell, Anselm; Ortiz, José L.; Escrivá, Juan; Fernández, Estrella; Pérez-Vizcaino, Francisco; Cogolludo, Ángel; Pastor, Enrique; Artigues, Enrique; Morcillo, Esteban; Cortijo, Julio BMJ (2018)
      Background Pulmonary hypertension (PH) is a common disorder in patients with idiopathic pulmonary fibrosis (IPF) and portends a poor prognosis. Recent studies using vasodilators approved for PH have failed in improving IPF ...

    • openAccess   Knowledge and Opinions of Healthcare Professionals about Thirdhand Smoke: A Multi-National, Cross-Sectional Study 

      Quispe-Cristóbal, Blanca; Lidón-Moyano, Cristina; Martín-Sánchez, Juan Carlos; Pérez-Martín, Hipólito; Cartanyà Hueso, Àurea; Cabriada-Sáez, Íñigo; de Paz-Cantos, Sonia; Martínez-Sánchez, Jose M; González-Marrón, Adrián MDPI (2022)
      There is scarce evidence on the knowledge and opinions about third-hand smoke (THS) of health care professionals. The main aim of this study was to explore the knowledge and opinions of health care professionals about ...

    • openAccess   Lack of MeCP2 leads to region-specific increase of doublecortin in the olfactory system 

      Martínez-Rodríguez, Elena; Martín Sánchez, Ana; Coviello, Simona; Foiani, Cristina; Kul, Emre; Martinez-Garcia, Fernando; Nacher, Juan; Lanuza, Enrique; Santos, Mónica; Agustín-Pavón, Carmen Springer (2019-05)
      The protein doublecortin is mainly expressed in migrating neuroblasts and immature neurons. The X-linked gene MECP2, associated to several neurodevelopmental disorders such as Rett syndrome, encodes the protein methyl-CpG-binding ...

    • openAccess   Laparoscopic treatment of a vesico-vaginal fistula: A new approach 

      Llueca, Antoni; Herraiz Roda, José Luis; Maazouzi, Yasmine; Piquer Simó, Dolors Sciedu Press (2016)
      Vesicovaginal fistulas (VVF) are among the most distressing complications of gynecologic and obstetric procedures. Management of these fistulas has been better defined and standardized over the last decade. VVF repair is ...

    • closedAccess   Large ovarian cysts assumed to be benign treated via laparoscopy 

      Herraiz Roda, José Luis; Llueca, Antoni; Català Masó, Carmen; Maazouzi, Yasmine; Colecha Morales, M.; Serra Rubert, Anna; Piquer Simó, Dolors; Oliva Martí, C.; Calpe Gómez, Enrique Springer Verlag (2015)
      The aim of this study was to assess the feasibility and outcome of laparoscopic surgery in the management of large ovarian cysts in patients treated at a university hospital. Twelve patients with large (diameter >10 cm) ...

    • openAccess   Laterally Extended Endopelvic Resection (Leer) and Reconstructive Techniques for Treatment of Locally Advanced Cervix Cancer: A Case Report 

      Llueca, Antoni; Herraiz Roda, José Luis; Boucher, Anna; Rodrigo, Miguel; Serra Rubert, Anna; Medina, Carmen; Guijarro Colomer, M.; Cañete Mota, A.; Maazouzi, Yasmine; Piquer Simó, Dolors; Barres, Jordan; De Francia, Stephan; Gimeno, Anna; Ferrer, Carlos; Escrig-Sos, Javier Graphy Publications (2016)
      The aim of this report is to describe the surgical procedure done in a 24-year-old woman who presents a locally advanced squamous cervix carcinoma and is proposed to laterally extended endopelvic resection (LEER), ...

    • closedAccess   Lesions of the dopaminergic innervation of the nucleus accumbens medial shell delay the generation of preference for sucrose, but not of sexual pheromones 

      Martínez-Hernández, José; Lanuza, Enrique; Martinez-Garcia, Fernando Elsevier (2012-01)
      Male sexual pheromones are rewarding stimuli for female mice, able to induce conditioned place preference. To test whether processing these natural reinforcing stimuli depends on the dopaminergic innervation of the nucleus ...

    • openAccess   Lipid profile, cardiovascular disease and mortality in a Mediterranean high-risk population: The ESCARVAL-RISK study 

      Orozco Beltrán, Domingo; Gil-Guillén, Vicente F; Redón, Josep; Martin-Moreno, Jose M.; Pallarés-Carratalá, Vicente; Navarro Pérez, Jorge; Valls Roca, Francisco; Sanchis-Domenech, Carlos; Fernández Giménez, Antonio; Pérez Navarro, Ana M.; Bertomeu-Martínez, Vicente; Cordero, Alberto; Pascual de la Torre, Manuel; Trillo, José L.; Carratala-Munuera, Concepcion; Pita Fernández, Salvador; Usó, Ruth; Durazo-Arvizu, Ramon; Cooper, Richard; Sanz, Ginés; Castellano, José M.; Ascaso, Juan F; Carmena, Rafael; Tellez-Plaza, Maria; ESCARVAL Study Group; Bertomeu-González, Vicente Public Library of Science (2017)
      Introduction The potential impact of targeting different components of an adverse lipid profile in populations with multiple cardiovascular risk factors is not completely clear. This study aims to assess the association ...

    • closedAccess   Lipoic acid lessens Th1-mediated inflammation in lipopolysaccharide-induced uveitis reducing selectively Th1 lymphocytes-related cytokines release 

      Mérida, S.; Sancho Tello, M.; Muriach Saurí, María; Miranda, M.; Navea, A.; Bosch Morell, F. Informa HealthCare (2013-08)
      Infl ammation results in the production of free radicals. We evaluated the anti-infl ammatory and antioxidant capacity of lipoic acid in an experimental uveitis model upon a subcutaneous injection of endotoxin into Lewis ...

    • closedAccess   Long telomere length and a TERT-CLPTM1 locus polymorphism association with melanoma risk 

      Llorca-Cardeñosa, Marta J.; Peña Chilet, María; Mayor, Matías; Gómez Fernández, Cristina; Casado, Beatriz; Martín González, Manuel; Carretero, Gregorio; Lluch , Ana; Martinez-Cadenas, Conrado; Ibarrola-Villava, Maider; Ribas, Gloria Elsevier (2014)
      Telomere length has been associated with the development of cancer. Studies have shown that shorter telomere length may be related to a decreased risk of cutaneous melanoma. Furthermore, deregulation of the telomere-maintaining ...

    • openAccess   Long term effects of peripubertal stress on excitatory and inhibitory circuits in the prefrontal cortex of male and female mice 

      BUENO FERNANDEZ, CLARA; Perez-Rando, Marta; Alcaide, Julia; Coviello, Simona; Sandi, Carmen; Castillo-Gómez, Esther; Nacher, Juan Elsevier ScienceDirect (2021-04-01)
      The impact of stressful events is especially important during early life, because certain cortical regions, especially the prefrontal cortex (PFC), are still developing. Consequently, aversive experiences that occur during ...

    • openAccess   Long-term recurrent events in ST-elevation myocardial infarction and multivessel disease. The impact of different revascularization strategies 

      Rumiz, Eva; Vilar, Juan Vicente; Cubillos, Andrés; Valero, Ernesto; Berenguer, Alberto; Fácila, Lorenzo; Vidal, Verónica; Fernandez, Carmen; Llopis Gisbert, Guillem; Paya, Rafael; Nuñez, Julio Elsevier (2023)
      Introduction The benefit of complete revascularization (CR) on long-term total event reduction in patients with ST-segment elevation myocardial infarction (STEMI) and multivessel disease (MVD), still remains unclear. ...

    • openAccess   Los desafíos del profesorado clínico en la educación médica 

      Palau, Patricia; Domínguez Mafé, Eloy; Llueca, Antoni; Nuñez, Julio; Bertomeu-González, Vicente; Sanchez-Andres, Juan V.; Pallarés-Carratalá, Vicente Elsevier (2017-11-04)
      Background: There is a unique particularity of clinical teaching in medical education that isbeyond knowledge, skills or teaching methods of each clinician: this is clinical teaching context.This study aimed to analyze the ...