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AAV delivery of shRNA against IRS1 in GABAergic neurons in rat hippocampus impairs spatial memory in females and male rats
Springer (2020-11-27)Brain insulin resistance is a major factor leading to impaired cognitive function and it is considered as the onset of Alzheimer´s disease. Insulin resistance is intimately linked to inflammatory conditions, many studies ... -
Abacavir induces platelet-endothelium interactions by interfering with purinergic signalling: A step from inflammation to thrombosis
Elsevier (2017-05)The controversy connecting Abacavir (ABC) with cardiovascular disease has been fuelled by the lack of a credible mechanism of action. ABC shares structural similarities with endogenous purines, signalling molecules capable ... -
Ablation of the tail of the ventral tegmental area compensates symptoms in an experimental model of Parkinson's disease
Elsevier (2020)Parkinson's disease is a neurodegenerative disorder partly caused by the loss of the dopamine neurons of the nigrostriatal pathway. It is accompanied by motor as well as non-motor symptoms, including pain and depression. ... -
Abscisic Acid Supplementation Rescues High Fat Diet-Induced Alterations in Hippocampal Inflammation and IRSs Expression
Springer (2018)Accumulated evidence indicates that neuroinflammation induces insulin resistance in the brain. Moreover, both processes are intimately linked to neurodegenerative disorders, including Alzheimer’s disease. Potential mechanisms ... -
Abscisic acid, a promising therapeutic molecule to prevent Alzheimer’s and neurodegenerative diseases
Medknow Publications (2020) -
Accelerated Polyethylene Terephthalate (PET) Enzymatic Degradation by Room Temperature Alkali Pre-treatment for Reduced Polymer Crystallinity
Wiley (2022-11-07)Polyethylene terephthalate (PET) is the most widely employed plastic for single-use applications. The use of enzymes isolated from microorganisms, such as PETase with the capacity to hydrolyze PET into its monomers, ... -
Actividad física y su relación con el estado de salud en pacientes EPOC estables
Elsevier España (Elsevier Doyma) (2011)Introducción Estudios previos han resaltado que la actividad física (AF) en la EPOC se asocia a mejor calidad de vida y menor morbimortalidad. Nuestro objetivo ha sido conocer los hábitos de AF en la vida diaria de ... -
Acute oral administration of low doses of methylphenidate targets calretinin neurons in the rat septal area
Frontiers Media (2015)Methylphenidate (MPD) is a commonly administered drug to treat children suffering from attention deficit hyperactivity disorder (ADHD). Alterations in septal driven hippocampal theta rhythm may underlie attention deficits ... -
Adaptive function and brain evolution
Frontiers (2012-05-29) -
Adaptive short-term associative conditioning in the pancreatic β-cell
Wiley (2020)This study associates cholinergic stimulation of the pancreatic β-cell electrical activity with a short-term memory phenomenon. Glucose pulses applied to a basal glucose concentration induce depolarizing waves which are ... -
Additional value of patient-reported symptom monitoring in cancer care: a systematic review of the literature
MDPI (2021)Background: To describe the benefit of patient-reported symptom monitoring on clinical, other patient-reported, and economic outcomes. Methods: We conducted a systematic literature review using Medline/PubMed, limited to ... -
Adenosine A(2A) and A(2B) Receptors Differentially Modulate Keratinocyte Proliferation: Possible Deregulation in Psoriatic Epidermis
Elsevier (2017-01)Adenosine is a potent regulator of inflammation and immunity, but the role of adenosine receptors in keratinocytes remains controversial. We determined that in addition to A2B receptors, human epidermal keratinocytes also ... -
Adherence, satisfaction and preferences for treatment in patients with psoriasis in the European Union: a systematic review of the literature
Dove Medical Press (2016)Background and objective: Adherence to treatment in patients with psoriasis is often poor. An investigation of patient preferences and satisfaction with treatment may be important, based on the expected correlation with ... -
Adicción al Fortnite con necesidad de desintoxicación hospitalaria
Asociación Española de Psiquiatria del Niño y del Adolescente (AEPNyA) (2021-06-30)La generalización del uso de nuevas tecnologías en la vida cotidiana y en aspectos relativos al ocio está sacando a relucir potenciales perjuicios del uso inadecuado de los videojuegos y la necesidad de tratamiento ... -
Adjusting and validating a procedure for parenteral anaesthesia in neonatal mice
Sage Publilcations (2024-03-18)For neonatal pups, parenteral anaesthesia is said to be not reliable as low doses induce no anaesthesia whereas high doses render high mortality rates. In this work we have adapted parenteral anaesthesia procedures approved ... -
Administration of docosahexaenoic acid before birth and until aging decreases kainate-induced seizures in adult zebrafish
Elsevier (2012-08-01)Docosahexaeonic acid (DHA) is the final compound in the omega-3 polyunsaturated fatty acids (PUFA) synthetic pathway and the most abundant PUFA found in the brain. DHA plays an essential role in the development of the ... -
Adolescent binge‐ethanol accelerates cognitive impairment and β‐amyloid production and dysregulates endocannabinoid signaling in the hippocampus of APP/PSE mice
Wiley (2020)Previous research in rodents suggests that the long‐term neurobehavioral disturbances induced by chronic ethanol (EtOH) exposure could be due to endocannabinoid system (ECS) alterations. Moreover, ECS failure has been ... -
Adverse pregnancy and perinatal outcomes in Latin America and the Caribbean: systematic review and meta-analysis
World Health Organization (2022)Objective. To estimate the point prevalence and likely ranges of pregnancy-induced hypertension, preeclampsia, gestational diabetes, low birth weight and preterm delivery in Latin America and the Caribbean, and evaluate ... -
Afferent and Efferent Connections of the Cortex-Amygdala Transition Zone in Mice
Frontiers Media (2016)The transitional zone between the ventral part of the piriform cortex and the anterior cortical nucleus of the amygdala, named the cortex-amygdala transition zone (CxA), shows two differential features that allow its ... -
Afferent and efferent projections of the anterior cortical amygdaloid nucleus in the mouse
Wiley (2017-06)The anterior cortical amygdaloid nucleus (ACo) is a chemosensory area of the cortical amygdala that receives afferent projections from both the main and accessory olfactory bulbs. The role of this structure is unknown, ...