Adaptive short-term associative conditioning in the pancreatic β-cell
comunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/36080
comunitat-uji-handle3:10234/36082
comunitat-uji-handle4:
INVESTIGACIONMetadatos
Título
Adaptive short-term associative conditioning in the pancreatic β-cellFecha de publicación
2020Editor
WileyISSN
2051-817XCita bibliográfica
Sanchez-Andres JV, Pomares R, Malaisse WJ. Adaptive short-term associative conditioning in the pancreatic β-cell. Physiol Rep. 2020;8:e14403. https://doi.org/10.14814/phy2.14403Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://physoc.onlinelibrary.wiley.com/doi/10.14814/phy2.14403Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
This study associates cholinergic stimulation of the pancreatic β-cell electrical activity with a short-term memory phenomenon. Glucose pulses applied to a basal
glucose concentration induce depolarizing waves which ... [+]
This study associates cholinergic stimulation of the pancreatic β-cell electrical activity with a short-term memory phenomenon. Glucose pulses applied to a basal
glucose concentration induce depolarizing waves which are used to estimate the evolution of the β-cell glucose sensitivity. Exposure to carbamoylcholine (carbachol)
increases the size of the glucose-induced depolarizing waves. This change appears
after carbachol withdrawal and implies a temporal potentiation of sensitivity (TPS)
lasting up to one hour. TPS induction requires the simultaneous action of carbachol
and glucose. The substitution of glucose with the secretagogues glyceraldehyde or
2-ketoisocaproate mimics glucose-induced TPS, while palmitate does not. TPS is not
produced if the membrane is kept hyperpolarized by diazoxide. Glucose can be replaced by tolbutamide, suggesting a role of depolarization and a subsequent increase
in intracellular calcium concentration. A role for kinases is suggested because staurosporine prevents TPS induction. Cycloheximide does not impair TPS induction,
indicating that de novo protein synthesis is not required. The fact that the two inputs
acting simultaneously produce an effect that lasts up to one hour without requiring de
novo protein synthesis suggests that TPS constitutes a case of short-term associative
conditioning in non-neural tissue. The convergence of basal glucose levels and muscarinic activation happens physiologically during the cephalic phase of digestion, in
order to later absorb incoming fuels. Our data reveals that the role of the cephalic
phase may be extended, increasing nutrient sensitivity during meals while remaining
low between them. [-]
Publicado en
Physiological Reports, 2020, vol. 8, no 6, p. e14403.Derechos de acceso
info:eu-repo/semantics/openAccess
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