Visualitza MED_Articles per autoria "b6d8dbbb-d824-41c3-b5f6-a3e548a0abe2"
Ara mostrant els elements 1-9 d 9
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A Strategy for Magnetic and Electric Stimulation to Enhance Proliferation and Differentiation of NPCs Seeded over PLA Electrospun Membranes
Cuenca Ortolá, Irene; Martínez Rojas, Beatriz; Moreno Manzano, Victoria; García Castelló, Marcos; Monleón Pradas, Manuel; Martínez Ramos, Cristina; Más-Estellés, Jorge MDPI (2022-11)Neural progenitor cells (NPCs) have been shown to serve as an efficient therapeutic strategy in different cell therapy approaches, including spinal cord injury treatment. Despite the reported beneficial effects of NPC ... -
Axonal extension from dorsal root ganglia on fibrillar and highly aligned poly(lactic acid)-polypyrrole substrates obtained by two different techniques: Electrospun nanofibres and extruded microfibres
Gisbert Roca, Fernando; Más-Estellés, Jorge; MONLEÓN PRADAS, MANUEL; Martinez Ramos, Cristina Elsevier (2020-09-24)The biological behaviour of Schwann cells (SCs) and dorsal root ganglia (DRG) on fibrillar, highly aligned and electroconductive substrates obtained by two different techniques is studied. Mats formed by nanometer-sized ... -
BDNF‐Gene Transfected Schwann Cell‐Assisted Axonal Extension and Sprouting on New PLA–PPy Microfiber Substrates
Gisbert Roca, Fernando; André, Franck M.; Más-Estellés, Jorge; MONLEÓN PRADAS, MANUEL; Mir, Luis M. Wiley (2021-03-01)The work here reported analyzes the effect of increased efficiency of brain‐derived neurotrophic factor (BDNF) production by electroporated Schwann cells (SCs) on the axonal extension in a coculture system on a biomaterial ... -
Biomaterials for Neural Tissue Engineering
Rodríguez Doblado, Laura; Martínez Ramos, Cristina; MONLEÓN PRADAS, MANUEL Frontiers Media (2021)The therapy of neural nerve injuries that involve the disruption of axonal pathways or axonal tracts has taken a new dimension with the development of tissue engineering techniques. When peripheral nerve injury (PNI), ... -
Conduits based on the combination of hyaluronic acid and silk fibroin: Characterization, in vitro studies and in vivo biocompatibility
Gisbert, Fernando; Lozano Picazo, Paloma; Pérez-Rigueiro, José; GUINEA TORTUERO, GUSTAVO VICTOR; MONLEÓN PRADAS, MANUEL; Martinez Ramos, Cristina Elsevier (2020-01-16)We address the production of structures intended as conduits made from natural biopolymers, capable of promoting the regeneration of axonal tracts. We combine hyaluronic acid (HA) and silk fibroin (SF) with the aim of ... -
Electrical Stimulation Increases Axonal Growth from Dorsal Root Ganglia Co-Cultured with Schwann Cells in Highly Aligned PLA-PPy-Au Microfiber Substrates
Martinez Ramos, Cristina; Gisbert Roca, Fernando; Serrano Requena, Sara; MONLEÓN PRADAS, MANUEL MDPI (2022-06-07)Nerve regeneration is a slow process that needs to be guided for distances greater than 5 mm. For this reason, different strategies are being studied to guide axonal growth and accelerate the axonal growth rate. In this ... -
Engineered axon tracts within tubular biohybrid scaffolds
Rodríguez Doblado, Laura; Martínez Ramos, Cristina; García-Verdugo, Jose Manuel; moreno manzano, Victoria; MONLEÓN PRADAS, MANUEL IOP Publishing (2021-08-12)Injuries to the nervous system that involve the disruption of axonal pathways are devastating to the individual and require specific tissue engineering strategies. Here we analyse a cells-biomaterials strategy to overcome ... -
Multimodular Bio-Inspired Organized Structures Guiding Long-Distance Axonal Regeneration
Rodríguez Doblado, Laura; Martínez Ramos, Cristina; Monleón Pradas, Manuel MDPI (2022-09)Axonal bundles or axonal tracts have an aligned and unidirectional architecture present in many neural structures with different lengths. When peripheral nerve injury (PNI), spinal cord injury (SCI), traumatic brain injury ... -
Novel Tissue-Engineered Multimodular Hyaluronic Acid-Polylactic Acid Conduits for the Regeneration of Sciatic Nerve Defect
Gisbert Roca, Fernando; Gil Santos, Luis; Mata Roig, Manuel; Milian Medina, Lara; Martínez Ramos, Cristina; Monleón Pradas, Manuel MDPI (2022-05)The gold standard for the treatment of peripheral nerve injuries, the autograft, presents several drawbacks, and engineered constructs are currently suitable only for short gaps or small diameter nerves. Here, we study a ...