Listar MED_Articles por autoría "42a125ab-80ab-4a67-968f-2dc34563d08e"
Mostrando ítems 1-20 de 20
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Beta‐blockers withdrawal in patients with heart failure with preserved ejection fraction and chronotropic incompetence: Effect on functional capacity rationale and study design of a prospective, randomized, controlled trial (The Preserve‐HR trial)
Palau, Patricia; Seller, Julia; Domínguez Mafé, Eloy; Gómez, Inés; Ramón, José María; Sastre, Clara; De la Espriella, Rafael; Santas, Enrique; Miñana, Gema; Chorro, Francisco J.; González Juanatey, José Ramón; Nuñez, Julio Wiley (2020)Background: The pathophysiology of heart failure with preserved ejection fraction (HFpEF) is complex and multifactorial. Chronotropic incompetence (ChI) has emerged as a crucial pathophysiological mechanism. Beta‐blockers, ... -
Chronotropic index and long-term outcomes in heart failure with preserved ejection fraction
Palau, Patricia; Domínguez Mafé, Eloy; Seller, Julia; Sastre, Clara; Sanchis, Juan; López, Laura; Bodí, Vicent; Llàcer, Pau; Miñana, Gema; De la Espriella, Rafael; Bayes-Genis, Antoni; Núñez, Julio Elsevier (2022)Introduction and objectives: Little is known about the usefulness of heart rate (HR) response to exercise for risk stratification in heart failure with preserved ejection fraction (HFpEF). Therefore, this study aimed ... -
Differential prognostic impact of type 2 diabetes mellitus in women and men with heart failure with preserved ejection fraction
Palau, Patricia; Bertomeu-González, Vicente; Sanchis, Juan; Soler Costa, Meritxell; De la Espriella, Rafael; Domínguez Mafé, Eloy; Santas, Enrique; Núñez, Eduardo; Chorro, Francisco J.; Miñana, Gema; Bayes-Genis, Antoni; Núñez, Julio Elsevier (2019)Introduction and objectives Type 2 diabetes mellitus (DM2) is a common comorbidity in patients with heart failure (HF) with preserved ejection fraction (HFpEF). Previous studies have shown that diabetic women are at ... -
Early effects of empagliflozin on exercise tolerance in patients with heart failure: A pilot study.
Núñez, Julio; Palau, Patricia; Domínguez Mafé, Eloy; Mollar, Anna; Núñez, Eduardo; Ramón, José María; Miñana, Gema; Santas, Enrique; Facila Rubio, Lorenzo; Górriz, José Luis; Sanchis, Juan; Bayes-Genis, Antoni Wiley (2018-04-17)Background: Sodium-glucose linked transporter 2 inhibition recently emerged as a promising ther- apy for reducing the risk of heart failure (HF) in patients with type 2 diabetes mellitus (T2DM). However, there is a lack ... -
Effect of a home-based inspiratory muscular training programme on functional capacity in patients with chronic COVID-19 after a hospital discharge: protocol for a randomised control trial (InsCOVID trial)
Palau, Patricia; Domínguez Mafé, Eloy; Sastre, Clara; Martínez Mas, María Luz; Gonzalez, Cruz; Bondía, Elvira; Albiach, Cristina; Núñez, Julio; López, Laura BMJ Publishing Group (2022)Introduction: Exercise intolerance and fatigue are the most common symptoms in patients with chronic COVID-19 after hospital discharge. Supervised exercise training programmes improve symptoms, but scarce research has been ... -
Effect of β-Blocker Withdrawal on Functional Capacity in Heart Failure and Preserved Ejection Fraction
Palau, Patricia; Seller, Julia; Domínguez Mafé, Eloy; Sastre, Clara; Ramón, Jose María; De la Espriella, Rafael; Santas, Enrique; Miñana, Gema; Bodí, Vicent; Sanchis, Juan; Valle, Alfonso; Chorro, F. Javier; Llácer, Pau; Bayes-Genis, Antoni; Núñez, Julio Elsevier (2021-11-15)BACKGROUND Chronotropic incompetence has shown to be associated with a decrease in exercise capacity in heart failure with preserved ejection fraction (HFpEF), yet b-blockers are commonly used in HFpEF despite the lack ... -
Entrenamiento de la musculatura inspiratoria y la electroestimulación muscular funcional en el tratamiento de la insuficiencia cardiaca con función sistólica conservada: estudio TRAINING-HF
Palau, Patricia; Domínguez Mafé, Eloy; López, Laura; Ramón, José María; Heredia, Raquel; González, Jessika; Santas, Enrique; Bodí, Vicent; Miñana, Gema; Valero, Ernesto; Mollar, Anna; Bertomeu-González, Vicente; Chorro, Francisco J.; Sanchis, Juan; Lupón, Josep; Bayes-Genis, Antoni; Núñez, Julio Elsevier (2018)Introducción y objetivos No se dispone de tratamientos farmacológicos que demuestren reducir la morbimortalidad asociada en pacientes con insuficiencia cardiaca y función sistólica conservada (IC-FEc). El objetivo del ... -
Heart rate response and functional capacity in patients with chronic heart failure with preserved ejection fraction
Domínguez Mafé, Eloy; Palau, Patricia; Núñez, Eduardo; Ramón, José María; López, Laura; Melero, Joana; Bellver, Alejandro; Santas, Enrique; Chorro, Francisco J.; Núñez, Julio Wiley (2018)Aims: The mechanisms of exercise intolerance in heart failure with preserved ejection fraction (HFpEF) are not yet elucidated. Chronotropic incompetence has emerged as a potential mechanism. We aimed to evaluate whether ... -
Home-based inspiratory muscle training for management of older patients with heart failure with preserved ejection fraction: does baseline inspiratory muscle pressure matter?
Palau, Patricia; Domínguez Mafé, Eloy; Ramón, José María; López, Laura; Briatore, Antonio Ernesto; Tormo, J. Pablo; Ventura, Bruno; Chorro, Francisco J.; Núñez, Julio SAGE (2019-05-31)Background: Heart failure with preserved ejection fraction is a clinical syndrome characterised by reduced exercise capacity. Some evidence has shown that a simple and home-based programme of inspiratory muscle training ... -
Inspiratory Muscle Function and Exercise Capacity in Patients with Heart Failure with Preserved Ejection Fraction
Palau, Patricia; Domínguez Mafé, Eloy; Núñez, Eduardo; Ramón, José María; López, Laura; Melero, Joana; Bellver, Alejandro; Chorro, Francisco J.; Bodí, Vicent; Bayes-Genis, Antoni; Sanchis, Juan; Núñez, Julio Elsevier (2017-06)Background Heart failure with preserved ejection fraction (HFpEF) is a clinical syndrome characterized by impaired exercise capacity resulting from dyspnea and fatigue. The pathophysiological mechanisms underlying the ... -
Inspiratory Muscle Training and Functional Electrical Stimulation for Treatment of Heart Failure With Preserved Ejection Fraction: Rationale and Study Design of a Prospective Randomized Controlled Trial
Palau, Patricia; Domínguez Mafé, Eloy; López, Laura; Heredia, Raquel; González, Jessika; Ramón, José María; Serra, Pilar; Santas, Enrique; Bodí, Vicent; Sanchis, Juan; Chorro, Francisco J.; Núñez, Julio Wiley (2016-08-02)Heart failure with preserved ejection fraction (HFpEF) has become the most prevalent form of heart failure in developed countries. Regrettably, there is no evidence-based effective therapy for HFpEF. We seek to evaluate ... -
Iron deficiency and short-term adverse events in patients with decompensated heart failure
Palau, Patricia; Llàcer, Pau; Domínguez Mafé, Eloy; Tormo, Juan Pablo; Zakarne, Rim; Mollar, Anna; Martínez, Ana; Miñana, Gema; Santas, Enrique; Almenar-Bonet, Luis; Fácila, Lorenzo; De la Espriella, Rafael; Núñez, Eduardo; Manzano, Luis; Bayes-Genis, Antoni; Núñez, Julio Springer (2021-03-15)Background: For patients with heart failure (HF), iron deficiency (ID) is a common therapeutic target. However, little is known about the utility of transferrin saturation (TSAT) or serum ferritin for risk stratification ... -
Isolated Partial Congenital Absence of the Pericardium: A Familial Presentation
Palau, Patricia; Domínguez Mafé, Eloy; García González, Pilar; Gallego Peris, Jorge; Bosch, María José; Sieso, Eduardo Elsevier (2015)Congenital defects of the pericardium are uncommon heart abnormalities. Most of the patients are asymptomatic and are usually diagnosed incidentally. Complications are more common in partial absence than in complete absence ... -
Los desafíos del profesorado clínico en la educación médica
Palau, Patricia; Domínguez Mafé, Eloy; Llueca, Antoni; Nuñez, Julio; Bertomeu-González, Vicente; Sanchez-Andres, Juan V.; Pallarés-Carratalá, Vicente Elsevier (2017-11-04)Background: There is a unique particularity of clinical teaching in medical education that isbeyond knowledge, skills or teaching methods of each clinician: this is clinical teaching context.This study aimed to analyze the ... -
Matrix metalloproteinase-12 cleaved fragment of titin as a predictor offunctional capacity in patients with heart failure and preserved ejection fraction
Palau, Patricia; Reese-Petersen, Alexander; Domínguez Mafé, Eloy; Ramón, José María; López, Laura; Mollar, Anna; Chorro, Francisco J.; Sanchis, Juan; Núñez, Julio Taylor and Francis (2020)Objectives.Serum levels of matrix metalloproteinase-12 cleaved fragment of titin (TIM), a novel circula-tory biomarker specific for cardiac titin degradation, has emerged as a potential biomarker in cardio-vascular diseases. ... -
Maximal functional capacity in subjects with isolated left bundle branch block: A pilot study
Palau, Patricia; Mendez, Jose; Santas, Enrique; Núñez, Julio; López López, Laura; Briatore, Antonio Ernesto; Domínguez Mafé, Eloy Wiley (2023-02-08)Background Left bundle branch block (LBBB) has been commonly associated with adverse cardiovascular (CV) events, but the effect of an isolated LBBB on maximal functional capacity is not well characterized. Objective To ... -
Sacubitril/valsartan and short-term changes in the 6-minute walk test: A pilot study
Beltrán, Paola; Palau, Patricia; Domínguez Mafé, Eloy; Faraudo, Mercedes; Núñez, Eduardo Elsevier (2018-02)Background Impaired exercise capacity is the most disabling symptom in patients with heart failure with reduced ejection fraction (HFrEF). Despite sacubitril/valsartan showing reduced long-term morbidity and mortality ... -
Sex differences on peak oxygen uptake in heart failure
Palau, Patricia; Domínguez Mafé, Eloy; Núñez, Julio Wiley (2019-10)Women represent nearly half of the adult heart failure (HF) population and they remain underrepresented in HF studies. We aimed to evaluate the evidence about peak oxygen uptake (peak VO2) for clinical stratification in ... -
Short-term effects of dapagliflozin on maximal functional capacity in heart failure with reduced ejection fraction (DAPA-VO2): a randomized clinical trial
Palau, Patricia; Amiguet Comins, Martina; Domínguez Mafé, Eloy; Sastre, Clara; Mollar, Anna; Seller, Julia; GARCIA-PINILLA, JOSE MANUEL; Larumbe, Ainoha; Valle, Alfonso; Gómez Doblas, Juan José; De la Espriella, Rafael; Miñana, Gema; Robles Mezcua, Ainhoa; Santas, Enrique; Bodí, Vicent; Sanchis, Juan; Pascual-Figal, Domingo A.; Gorriz, Jose Luis; Bayes-Genis, Antoni; Núñez, Julio Wiley (2022-05-23)Aims This study aimed to evaluate the effect of dapagliflozin on 1 and 3-month maximal functional capacity in patients with stable heart failure with reduced ejection fraction (HFrEF). Methods and results In this ... -
Six-minute walk test in moderate to severe heart failure with preserved ejection fraction: Useful for functional capacity assessment?
Palau, Patricia; Domínguez Mafé, Eloy; Núñez, Eduardo; Sanchis, Juan; Santas, Enrique; Núñez, Julio Elsevier (2016-01-15)Despite improvements in medical treatment and prevention, heart failure (HF) remains a major cause of morbidity and mortality worldwide [1]. Currently, HF with preserved ejection fraction (HFpEF) has become the most prevalent ...