Inspiratory Muscle Training and Functional Electrical Stimulation for Treatment of Heart Failure With Preserved Ejection Fraction: Rationale and Study Design of a Prospective Randomized Controlled Trial
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Otros documentos de la autoría: Palau, Patricia; Domínguez Mafé, Eloy; López, Laura; Heredia, Raquel; González, Jessika; Ramón, José María; Serra, Pilar; Santas, Enrique; Bodí, Vicent; Sanchis, Juan; Chorro, Francisco J.; Núñez, Julio
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http://dx.doi.org/10.1002/clc.22555 |
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Título
Inspiratory Muscle Training and Functional Electrical Stimulation for Treatment of Heart Failure With Preserved Ejection Fraction: Rationale and Study Design of a Prospective Randomized Controlled TrialAutoría
Fecha de publicación
2016-08-02Editor
WileyCita bibliográfica
PALAU SAMPIO, Patricia; DOMÍMNGUEZ MAFÉ, Eloy; LÓPEZ, Laura; HEREDIA, Raquel; GONZÁLEZ, Jessika; RAMÓN, José María; SERRA, Pilar; SANTAS, Enrique; BODÍ, Vicent; SANCHIS, Juan; CHORRO, Francisco J.; NÚÑEZ, Julio. nspiratory Muscle Training and Functional Electrical Stimulation for Treatment of Heart Failure With Preserved Ejection Fraction: Rationale and Study Design of a Prospective Randomized Controlled Trial. Clinical Cardiology (2016), v. 39, p. 8, pp. 433-439Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://onlinelibrary.wiley.com/doi/10.1002/clc.22555/abstract;jsessionid=9DED582 ...Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Heart failure with preserved ejection fraction (HFpEF) has become the most prevalent form of heart failure
in developed countries. Regrettably, there is no evidence-based effective therapy for HFpEF. We seek to
ev ... [+]
Heart failure with preserved ejection fraction (HFpEF) has become the most prevalent form of heart failure
in developed countries. Regrettably, there is no evidence-based effective therapy for HFpEF. We seek to
evaluate whether inspiratory muscle training, functional electrical stimulation, or a combination of both can
improve exercise capacity as well as left ventricular diastolic function, biomarker profile, quality of life (QoL),
and prognosis in patients with HFpEF. A total of 60 stable symptomatic patients with HFpEF (New York
Heart Association class II–III/IV) will be randomized (1:1:1:1) to receive a 12-week program of inspiratory
muscle training, functional electrical stimulation, a combination of both, or standard care alone. The primary
endpoint of the study is change in peak exercise oxygen uptake; secondary endpoints are changes in QoL,
echocardiogram parameters, and prognostic biomarkers. As of March 21, 2016, thirty patients have been
enrolled. Searching for novel therapies that improve QoL and autonomy in the elderly with HFpEF has become
a health care priority. We believe that this study will add important knowledge about the potential utility of 2
simple and feasible physical interventions for the treatment of advanced HFpEF. [-]
Publicado en
Clinical Cardiology (2016), v. 39, p. 8Derechos de acceso
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