Listar IUPA_Articles por autoría "6ac3004e-12c4-4767-91fd-bab521dbf653"
Mostrando ítems 1-20 de 28
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A case study on pharmaceutical residues and antimicrobial resistance genes in Costa Rican rivers: A possible route of contamination for feline and other species
VARGAS, SEILING; Hernandez, Felix; Fabregat-Safont, David; Salas González, Denis Mauricio; Quesada-Alvarado, Francisco; Botero-Coy, Ana Maria; ESPERON, FERNANDO; Martín-Maldonado, Bárbara; Monros, Juan Salvador; Ruepert, Clemens; Estrada, Sandra; Rivera-Castillo, Josué; Chaverri, Fabio; Blanco-Peña, Kinndle Elsevier (2023-11-21)In this investigation, the presence of antibiotics and pharmaceuticals in Costa Rican surface waters, specifically in regions near feline habitats, was examined. The study revealed that 47% of the water samples contained ... -
Analytical key issues and challenges in the LC-MS/MS determination of antibiotics in wastewater
Fabregat-Safont, David; Gracia-Marín, Elisa; Ibañez Martinez, Maria; Pitarch, Elena; Hernandez, Felix (2023-01-25)The research on antibiotics occurrence in the aquatic environment has become a hot topic in the last years due to their potential negative effects, associated to possible bacterial antibiotic-resistance, after continuous ... -
Analytical methodologies based on LC–MS/MS for monitoring selected emerging compounds in liquid and solid phases of the sewage sludge
Boix Sales, Clara; Ibáñez, Maria; Fabregat-Safont, David; Morales, E.; Pastor, L.; Sancho, Juan V; Sánchez-Ramírez, J. E.; Hernandez, Felix Elsevier (2016)In this work, two analytical methodologies based on liquid chromatography coupled to tandem mass spectrometry (LC–MS/MS) were developed for quantification of emerging pollutants identified in sewage sludge after a previous ... -
Analytical research of pesticide biomarkers in wastewater with application to study spatial differences in human exposure
Campos-Mañas, Marina Celia; Fabregat-Safont, David; Hernandez, Felix; de Rijke, Eva; de Voogt, Pim; van Wezel, Annemarie; Bijlsma, Lubertus Elsevier (2022-07-15)Wastewater-based epidemiology (WBE) relies on the assessment and interpretation of levels of biomarkers in wastewater originating from a well-defined community. It has provided unique information on spatial and temporal ... -
Behaviour of emerging contaminants in sewage sludge after anaerobic digestion
Boix Sales, Clara; Ibáñez, Maria; Fabregat-Safont, David; Morales, E.; Pastor, L.; Sancho, Juan V; Sánchez-Ramírez, J. E.; Hernandez, Felix Elsevier (2016)Nowadays, there is an increasing concern over the presence of contaminants in the aquatic environment, where they can be introduced from wastewater after their incomplete removal in the treatment plants. In this work, ... -
Benefits of Ion Mobility Separation in GC-APCI-HRMS Screening: From the Construction of a CCS Library to the Application to Real-World Samples
Izquierdo-Sandoval, David; Fabregat-Safont, David; Lacalle-Bergeron, Leticia; Sancho, Juan V; Hernandez, Felix; Portoles, Tania American Chemical Society (2022-06-28)The performance of gas chromatography (GC) combined with the improved identification properties of ion mobility separation coupled to high-resolution mass spectrometry (IMS-HRMS) is presented as a promising approach for ... -
Characterization of the recently detected cathinone N-cyclohexyl butylone: From structure elucidation to in silico supported pharmacological/ toxicological considerations
Mata-Pesquera, María; Fabregat-Safont, David; Gil, Cristina; Ventura, Mireia; Steinmetz, Fabian P.; Ibáñez, María Elsevier (2023)One of the most widely consumed new psychoactive substances (NPS) families in Europe are synthetic cathinones. Cathinone structure can be easily modified resulting in new derivatives that rapidly reach drug markets. In ... -
Comprehensive investigation on synthetic cannabinoids: metabolic behaviour, detectability and potency testing, using 5F-APP-PICA and AMBFUBINACA as model compounds.
Fabregat-Safont, David; Mardal, Marie; Noble, Carolina; Cannaert, Annelies; Stove, Christophe; Sancho, Juan V; Linner, Kristian; Hernandez, Felix; Ibáñez, Maria Wiley (2019-09)Synthetic cannabinoids (SCs) represented 45% of new psychoactive substances seizures in Europe (data from 2016). The consumption of SCs is an issue of concern due to their still unknown toxicity and effects on human health, ... -
Comprehensive study on the potential environmental risk of temporal antibiotic usage through wastewater discharges
Gracia-Marín, Elisa; Rico, Andreu; Fabregat-Safont, David; Lopez, Francisco; Hernandez, Felix; Pitarch, Elena; Bijlsma, Lubertus Elsevier (2023-10-31)Antibiotic residues can reach aquatic ecosystems through urban wastewater discharges, posing an ecotoxicological risk for aquatic organisms and favoring the development of bacterial resistance. To assess the emission rate ... -
Development of a simple and low-cost prototype probe fully-compatible with atmospheric solids analysis probe for the analysis of human breath in real-time
Fabregat-Safont, David; Ibañez Martinez, Maria; Hernandez, Felix; Sancho, Juan V Elsevier (2021-12-16)The analysis in real-time of the exhaled breath has gained great attention in the last years due to the high number of possible applications, such as the investigation of endogenous compounds, the detection of disease ... -
Direct and Fast Screening of New Psychoactive Substances Using Medical Swabs and Atmospheric Solids Analysis Probe Triple Quadrupole with Data-Dependent Acquisition
Fabregat-Safont, David; Felis-Brittes, Daniela; Mata-Pesquera, Maria; Sancho, Juan V; Hernandez, Felix; Ibáñez, Maria American Chemical Society (2020-05-28)New psychoactive substances (NPS) have become a serious public health problem, as they are continuously changing their structures and modifying their potency and effects on humans, and therefore, novel compounds are ... -
Efficient Validation Strategies in Environmental Analytical Chemistry: A Focus on Organic Micropollutants in Water Samples
Hernandez, Felix; Fabregat-Safont, David; Campos-Mañas, Marina Celia; Quintana, José Benito Annual Reviews (2023)This article critically reviews analytical method validation and quality control applied to the environmental chemistry field. The review focuses on the determination of organic micropollutants (OMPs), specifically emerging ... -
Electrochemical oxidation of meglumine in a pharmaceutical formulation using a nanocomposite anode
Lozano Gutiérrez, G. I.; Ornelas Dávila, Omar; López Aguilar, C.; Dávila-Jiménez, Martín M.; Silva-González, Rutilo; Sirés Sadornil, Ignacio; Fabregat-Safont, David; Roig-Navarro, Antoni F.; Beltran Arandes, Joaquin; Sancho Llopis, Juan Vicente Elsevier (2022-10-30)The electrocatalytic oxidation of meglumine and gadoterate meglumine (Gd-DOTA) on a TiO2-Ni(SO4)0.3(OH)1.4 composite anode was investigated in alkaline medium (5 M KOH) using cyclic voltammetry and chronoamperometry. The ... -
Identification and characterization of a putative new psychoactive substance, 2-(2-(4-chlorophenyl)acetamido)- 3-methylbutanamide, in Spain
Fabregat-Safont, David; Fornís, I.; Ventura, Mireia; Gil, C.; Calzada, N.; Sancho, Juan V; Hernandez, Felix; Ibáñez, Maria Wiley (2017-02-28)The term ‘new psychoactive substances’ (NPS) refers to synthetically changed natural compounds or newly designed compounds intended to elicit a psychotropic response such as stimulation, hallucination or sedation. According ... -
Improving Target and Suspect Screening High-Resolution Mass Spectrometry Workflows in Environmental Analysis by Ion Mobility Separation
Celma, Alberto; Sancho, Juan V; Schymanski, Emma; Fabregat-Safont, David; Ibáñez, Maria; Goshawk, Jeff; Barknowitz, Gitte; Hernandez, Felix; Bijlsma, Lubertus American Chemical Society (2020-11-19)Currently, the most powerful approach to monitor organic micropollutants (OMPs) in environmental samples is the combination of target, suspect, and nontarget screening strategies using high-resolution mass spectrometry ... -
In-depth comparison of the metabolic and pharmacokinetic behaviour of the structurally related synthetic cannabinoids AMB-FUBINACA and AMB-CHMICA in rats
Fabregat-Safont, David; Mata-Pesquera, Maria; Barneo-Muñoz, Manuela; Martinez-Garcia, Fernando; Mardal, Marie; Davidsen, Anders Bork; Sancho, Juan V; Hernandez, Felix; Ibañez Martinez, Maria Springer Nature (2022-02-24)Synthetic cannabinoids receptor agonists (SCRAs) are often almost completely metabolised, and hence their pharmacokinetics should be carefully evaluated for determining the most adequate biomarker in toxicological analysis. ... -
Investigation on the consumption of synthetic cannabinoids among teenagers by the analysis of herbal blends and urine samples
Fabregat-Safont, David; Ibáñez, Maria; baquero, abel; Sancho, Juan V; Hernandez, Felix; Haro Cortés, Gonzalo Elsevier (2020-04-13)The use of synthetic cannabinoids (SCs), which escape conventional detection systems, may be a good alternative to elude routine drug analysis for cannabis. The detection of these drugs in urine is unusual due to their ... -
Metabolic profiling of four synthetic stimulants, including the novel indanyl-cathinone 5-PPDi, after human hepatocyte incubation
Fabregat-Safont, David; Mardal, Marie; Sancho, Juan V; Hernandez, Felix; Linnet, Kristjan; Ibáñez, Maria Elsevier (2019-12-28)Synthetic cathinones are new psychoactive substances that represent a health risk worldwide. For most of the 130 reported compounds, information about toxicology and/or metabolism is not available, which hampers their ... -
Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
Costa-Machado, Luis Filipe; García-Domínguez, Esther; McIntyre, Rebecca L.; Lopez Aceituno, Jose Luis; Ballesteros-González, Álvaro; Tapia-Gonzalez, Andrea; Fabregat-Safont, David; Eisenberg, Tobias; Gómez, Jesús; Plaza, Adrian; Sierra Ramírez, Arantzazu; Pérez, Manuel; Villanueva Bermejo, David; Fornari, Tiziana; Loza García, María Isabel; Herradón, Gonzalo; Hofer, Sebastian; Magnes, Christoph; Madeo, Frank; Duerr, Janet S.; Pozo, Oscar; Galindo, Máximo Ibo; del Pino, Isabel; Houtkooper, Riekelt H.; Megias, Diego; Viña, José; Gomez-Cabrera , Mari Carmen; Fernandez-Marcos, Pablo J. Nature Research (2023)Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show ... -
Proposal of 5-methoxy-N-methyl-N-isopropyltryptamine consumption biomarkers through identification of in vivo metabolites from mice
Fabregat-Safont, David; Barneo-Muñoz, Manuela; Martinez-Garcia, Fernando; Sancho, Juan V; Hernandez, Felix; Ibáñez, Maria Elsevier (2017-07)New psychoactive substances (NPS) are a new breed of synthetically produced substances designed to mimic the effects of traditional illegal drugs. Synthetic cannabinoids and synthetic cathinones are the two most common ...