Benefits of Ion Mobility Separation in GC-APCI-HRMS Screening: From the Construction of a CCS Library to the Application to Real-World Samples
Impacto
Scholar |
Otros documentos de la autoría: Izquierdo-Sandoval, David; Fabregat-Safont, David; Lacalle-Bergeron, Leticia; Sancho, Juan V; Hernandez, Felix; Portoles, Tania
Metadatos
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INVESTIGACIONMetadatos
Título
Benefits of Ion Mobility Separation in GC-APCI-HRMS Screening: From the Construction of a CCS Library to the Application to Real-World SamplesAutoría
Fecha de publicación
2022-06-28Editor
American Chemical SocietyISSN
0003-2700; 1520-6882Cita bibliográfica
Izquierdo-Sandoval, D., Fabregat-Safont, D., Lacalle-Bergeron, L., Sancho, J. V., Hernández, F., Portoles, T. Benefits of Ion Mobility Separation in GC-APCI-HRMS Screening: From the Construction of a CCS Library to the Application to Real-World Samples. Anal. Chem. 2022, 94, 25, 9040-9047, DOI: 10.1021/acs.analchem.2c01118Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://pubs.acs.org/doi/full/10.1021/acs.analchem.2c01118Versión
info:eu-repo/semantics/submittedVersionPalabras clave / Materias
Resumen
The performance of gas chromatography (GC) combined with the improved identification properties of ion mobility separation coupled to high-resolution mass spectrometry (IMS-HRMS) is presented as a promising approach ... [+]
The performance of gas chromatography (GC) combined with the improved identification properties of ion mobility separation coupled to high-resolution mass spectrometry (IMS-HRMS) is presented as a promising approach for the monitoring of (semi)volatile compounds in complex matrices. The soft ionization promoted by an atmospheric pressure chemical ionization (APCI) source designed for GC preserves the molecular and/or quasi-molecular ion information enabling a rapid, sensitive, and efficient wide-scope screening. Additionally, ion mobility separation (IMS) separates species of interest from coeluting matrix interferences and/or resolves isomers based on their charge, shape, and size, making IMS-derived collision cross section (CCS) a robust and matrix-independent parameter comparable between instruments. In this way, GC-APCI-IMS-HRMS becomes a powerful approach for both target and suspect screening due to the improvements in (tentative) identifications. In this work, mobility data for 264 relevant multiclass organic pollutants in environmental and food-safety fields were collected by coupling GC-APCI with IMS-HRMS, generating CCS information for molecular ion and/or protonated molecules and some in-source fragments. The identification power of GC-APCI-IMS-HRMS for the studied compounds was assessed in complex-matrix samples, including fish feed extracts, surface waters, and different fruit and vegetable samples. [-]
Publicado en
Analytical Chemistry, 2022, vol. 94, no 25Entidad financiadora
Ministerio de Educación y Formación Profesional | Ministerio de Economía y Competitividad | Universitat Jaume I
Código del proyecto o subvención
FPU19/01839 | RYC-2017-22525 | UJI-B2020-37
Derechos de acceso
Copyright © American Chemical Society
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info:eu-repo/semantics/openAccess
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info:eu-repo/semantics/openAccess
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