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Untargeted metabolomics unravels distinct gut microbial metabolites derived from plant-based and animal-origin proteins using in vitro modeling
dc.contributor.author | Izquierdo-Sandoval, David | |
dc.contributor.author | Duan, Xiang | |
dc.contributor.author | Fryganas, Christos | |
dc.contributor.author | Portoles, Tania | |
dc.contributor.author | Sancho, Juan Vicente | |
dc.contributor.author | Rubert, Josep | |
dc.date.accessioned | 2024-06-28T11:59:03Z | |
dc.date.available | 2024-06-28T11:59:03Z | |
dc.date.issued | 2024-11-01 | |
dc.identifier.citation | David Izquierdo-Sandoval, Xiang Duan, Christos Fryganas, Tania Portolés, Juan Vicente Sancho, Josep Rubert, Untargeted metabolomics unravels distinct gut microbial metabolites derived from plant-based and animal-origin proteins using in vitro modeling, Food Chemistry, Volume 457, 2024, 140161, ISSN 0308-8146, https://doi.org/10.1016/j.foodchem.2024.140161. | ca_CA |
dc.identifier.issn | 03088146 | |
dc.identifier.uri | http://hdl.handle.net/10234/207919 | |
dc.description.abstract | The popularity of plant-based meat alternatives (PBMAs) has sparked a contentious debate about their influence on intestinal homeostasis compared to traditional animal-based meats. This study aims to explore the changes in gut microbial metabolites (GMMs) induced by the gut microbiota on different digested patties: beef meat and pea-protein PBMA. After digesting in vitro, untargeted metabolomics revealed 32 annotated metabolites, such as carnitine and acylcarnitines correlated with beef meat, and 45 annotated metabolites, like triterpenoids and lignans, linked to our PBMA. Secondly, (un)targeted approaches highlighted differences in GMM patterns during colonic fermentations. Our findings underscore significant differences in amino acids and their derivatives. Beef protein fermentation resulted in higher production of methyl-histidine, gamma-glutamyl amino acids, indoles, isobutyric and isovaleric acids. In contrast, PBMAs exhibit a significant release of N-acyl amino acids and unique dipeptides, like phenylalanine-arginine. This research offers valuable insights into how PBMAs and animal-based proteins differently modulate intestinal microenvironments. | ca_CA |
dc.format.extent | 13 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Elsevier Ltd | ca_CA |
dc.relation.isPartOf | Food Chemistry, Volume 457, 2024. | ca_CA |
dc.rights | © 2024 The Author(s) | ca_CA |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | ca_CA |
dc.subject | Gut microbial metabolites | ca_CA |
dc.subject | Protein fermentation | ca_CA |
dc.subject | Plant-based proteins | ca_CA |
dc.subject | Metabolomics | ca_CA |
dc.subject | High-resolution mass spectrometry | ca_CA |
dc.title | Untargeted metabolomics unravels distinct gut microbial metabolites derived from plant-based and animal-origin proteins using in vitro modeling | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | 10.1016/j.foodchem.2024.140161 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | https://www.sciencedirect.com/science/article/pii/S0308814624018119 | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
project.funder.name | Ministry of Science and Technology National Foreign Experts Program | ca_CA |
project.funder.name | Ministerio de Ciencia, Innovación y Universidades | ca_CA |
project.funder.name | Ministerio de Economía y Competitividad | ca_CA |
oaire.awardNumber | FPU19/01839 | ca_CA |
oaire.awardNumber | 20231047 | ca_CA |
oaire.awardNumber | RYC-2017-22525, PID2021-127346NB-I00 | ca_CA |
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