Untargeted metabolomics unravels distinct gut microbial metabolites derived from plant-based and animal-origin proteins using in vitro modeling
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Títol
Untargeted metabolomics unravels distinct gut microbial metabolites derived from plant-based and animal-origin proteins using in vitro modelingAutoria
Data de publicació
2024-11-01Editor
Elsevier LtdISSN
03088146Cita bibliogràfica
David Izquierdo-Sandoval, Xiang Duan, Christos Fryganas, Tania Portolés, Juan Vicente Sancho, Josep Rubert, Untargeted metabolomics unravels distinct gut microbial metabolites derived from plant-based and animal-origin proteins using in vitro modeling, Food Chemistry, Volume 457, 2024, 140161, ISSN 0308-8146, https://doi.org/10.1016/j.foodchem.2024.140161.Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
https://www.sciencedirect.com/science/article/pii/S0308814624018119Versió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
The popularity of plant-based meat alternatives (PBMAs) has sparked a contentious debate about their influence on intestinal homeostasis compared to traditional animal-based meats. This study aims to explore the changes ... [+]
The popularity of plant-based meat alternatives (PBMAs) has sparked a contentious debate about their influence on intestinal homeostasis compared to traditional animal-based meats. This study aims to explore the changes in gut microbial metabolites (GMMs) induced by the gut microbiota on different digested patties: beef meat and pea-protein PBMA. After digesting in vitro, untargeted metabolomics revealed 32 annotated metabolites, such as carnitine and acylcarnitines correlated with beef meat, and 45 annotated metabolites, like triterpenoids and lignans, linked to our PBMA. Secondly, (un)targeted approaches highlighted differences in GMM patterns during colonic fermentations. Our findings underscore significant differences in amino acids and their derivatives. Beef protein fermentation resulted in higher production of methyl-histidine, gamma-glutamyl amino acids, indoles, isobutyric and isovaleric acids. In contrast, PBMAs exhibit a significant release of N-acyl amino acids and unique dipeptides, like phenylalanine-arginine. This research offers valuable insights into how PBMAs and animal-based proteins differently modulate intestinal microenvironments. [-]
Publicat a
Food Chemistry, Volume 457, 2024.Entitat finançadora
Ministry of Science and Technology National Foreign Experts Program | Ministerio de Ciencia, Innovación y Universidades | Ministerio de Economía y Competitividad
Codi del projecte o subvenció
FPU19/01839 | 20231047 | RYC-2017-22525, PID2021-127346NB-I00
Drets d'accés
© 2024 The Author(s)
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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