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dc.contributor.authorTENO, JORGE
dc.contributor.authorPardo-Figuerez, Maria
dc.contributor.authorEvtoski, Zoran
dc.contributor.authorPrieto, Cristina
dc.contributor.authorCabedo, Luis
dc.contributor.authorLAGARON, Jose
dc.date.accessioned2024-05-16T10:39:40Z
dc.date.available2024-05-16T10:39:40Z
dc.date.issued2024-02-03
dc.identifier.citationTeno, Jorge, Maria Pardo-Figuerez, Zoran Evtoski, Cristina Prieto, Luis Cabedo, and Jose M. Lagaron. 2024. "Development of Ciprofloxacin-Loaded Electrospun Yarns of Application Interest as Antimicrobial Surgical Suture Materials" Pharmaceutics 16, no. 2: 220.ca_CA
dc.identifier.issn1999-4923
dc.identifier.urihttp://hdl.handle.net/10234/207362
dc.description.abstractSurgical site infections (SSI) occur very frequently during post-operative procedures and are often treated with oral antibiotics, which may cause some side effects. This type of infection could be avoided by encapsulating antimicrobial/anti-inflammatory drugs within the surgical suture materials so that they can more efficiently act on the site of action during wound closure, avoiding post-operative bacterial infection and spreading. This work was aimed at developing novel electrospun bio-based anti-infective fibre-based yarns as novel suture materials for preventing surgical site infections. For this, yarns based on flying intertwined microfibres (1.95 ± 0.22 µm) were fabricated in situ during the electrospinning process using a specially designed yarn collector. The electrospun yarn sutures (diameter 300–500 µm) were made of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) with different contents of 3HV units and contained ciprofloxacin hydrochloride (CPX) as the antimicrobial active pharmaceutical ingredient (API). The yarns were then analysed by scanning electron microscopy, Fourier transform infrared spectroscopy, wide-angle X-ray scattering, differential scanning calorimetry, and in vitro drug release. The yarns were also analysed in terms of antimicrobial and mechanical properties. The material characterization indicated that the varying polymer molecular architecture affected the attained polymer crystallinity, which was correlated with the different drug-eluting profiles. Moreover, the materials exhibited the inherent stiff behaviour of PHBV, which was further enhanced by the API. Lastly, all the yarn sutures presented antimicrobial properties for a time release of 5 days against both Gram-positive and Gram-negative pathogenic bacteria. The results highlight the potential of the developed antimicrobial electrospun yarns in this study as potential innovative suture materials to prevent surgical infections.ca_CA
dc.format.extent16 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherMDPIca_CA
dc.relation.isPartOfPharmaceutics Vol. 16, Iss. 2 (2024)ca_CA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/ca_CA
dc.subjectPHBVsca_CA
dc.subjectelectrospinningca_CA
dc.subjectsuture yarnca_CA
dc.subjectantimicrobial activityca_CA
dc.titleDevelopment of ciprofloxacin-loaded electrospun yarns of application interest as antimicrobial surgical suture materialsca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttps://doi.org/10.3390/pharmaceutics16020220
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_CA
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_CA
project.funder.nameAgencia Valenciana de Innovación (AVI)ca_CA
project.funder.nameSpanish Ministry of Science and Innovation (MICIN)ca_CA
oaire.awardNumberINNEST/2022/3-25-64ca_CA
oaire.awardNumberPID2021-128749OB-C31 | TED2021-130211B-C32ca_CA


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