Development of ciprofloxacin-loaded electrospun yarns of application interest as antimicrobial surgical suture materials
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INVESTIGACIONMetadatos
Título
Development of ciprofloxacin-loaded electrospun yarns of application interest as antimicrobial surgical suture materialsAutoría
Fecha de publicación
2024-02-03Editor
MDPIISSN
1999-4923Cita bibliográfica
Teno, Jorge, Maria Pardo-Figuerez, Zoran Evtoski, Cristina Prieto, Luis Cabedo, and Jose M. Lagaron. 2024. "Development of Ciprofloxacin-Loaded Electrospun Yarns of Application Interest as Antimicrobial Surgical Suture Materials" Pharmaceutics 16, no. 2: 220.Tipo de documento
info:eu-repo/semantics/articleVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Surgical site infections (SSI) occur very frequently during post-operative procedures and are often treated with oral antibiotics, which may cause some side effects. This type of infection could be avoided by encaps ... [+]
Surgical site infections (SSI) occur very frequently during post-operative procedures and are often treated with oral antibiotics, which may cause some side effects. This type of infection could be avoided by encapsulating antimicrobial/anti-inflammatory drugs within the surgical suture materials so that they can more efficiently act on the site of action during wound closure, avoiding post-operative bacterial infection and spreading. This work was aimed at developing novel electrospun bio-based anti-infective fibre-based yarns as novel suture materials for preventing surgical site infections. For this, yarns based on flying intertwined microfibres (1.95 ± 0.22 µm) were fabricated in situ during the electrospinning process using a specially designed yarn collector. The electrospun yarn sutures (diameter 300–500 µm) were made of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) with different contents of 3HV units and contained ciprofloxacin hydrochloride (CPX) as the antimicrobial active pharmaceutical ingredient (API). The yarns were then analysed by scanning electron microscopy, Fourier transform infrared spectroscopy, wide-angle X-ray scattering, differential scanning calorimetry, and in vitro drug release. The yarns were also analysed in terms of antimicrobial and mechanical properties. The material characterization indicated that the varying polymer molecular architecture affected the attained polymer crystallinity, which was correlated with the different drug-eluting profiles. Moreover, the materials exhibited the inherent stiff behaviour of PHBV, which was further enhanced by the API. Lastly, all the yarn sutures presented antimicrobial properties for a time release of 5 days against both Gram-positive and Gram-negative pathogenic bacteria. The results highlight the potential of the developed antimicrobial electrospun yarns in this study as potential innovative suture materials to prevent surgical infections. [-]
Publicado en
Pharmaceutics Vol. 16, Iss. 2 (2024)Entidad financiadora
Agencia Valenciana de Innovación (AVI) | Spanish Ministry of Science and Innovation (MICIN)
Código del proyecto o subvención
INNEST/2022/3-25-64 | PID2021-128749OB-C31 | TED2021-130211B-C32
Derechos de acceso
info:eu-repo/semantics/openAccess
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