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ABA Supplementation Rescues IRS2 and BDNF mRNA Levels in a Triple-Transgenic Mice Model of Alzheimer’s Disease
dc.contributor.author | Alves-Borba, Laryssa | |
dc.contributor.author | Espinosa-Fernández, Veronica | |
dc.contributor.author | Canseco Rodriguez, Ania | |
dc.contributor.author | Sanchez-Pérez, Ana María | |
dc.date.accessioned | 2024-04-09T12:55:28Z | |
dc.date.available | 2024-04-09T12:55:28Z | |
dc.date.issued | 2023-09-08 | |
dc.identifier.citation | Alves-Borba, Laryssa et al. ‘ABA Supplementation Rescues IRS2 and BDNF mRNA Levels in a Triple-Transgenic Mice Model of Alzheimer’s Disease’. 1 Jan. 2023 : 1007 – 1013. | ca_CA |
dc.identifier.issn | 2542-4823 | |
dc.identifier.uri | http://hdl.handle.net/10234/206372 | |
dc.description.abstract | Insulin resistance underlies Alzheimer’s disease (AD) by affecting neuroinflammation and brain-derived neurotrophic factor (BDNF) expression. Here, we evaluated the effect of early and late-start abscisic acid (ABA) intervention on hippocampal BDNF, tumor necrosis factor α (TNFα), and insulin receptors substrates (IRS) 1/2 mRNA levels in a triple-transgenic mice model of AD. Transgenic mice displayed lower BDNF and IRS2, equal IRS1, and higher TNFα expression compared to wild-type mice. Late ABA treatment could rescue TNFα and increased IRS1/2 expression. However, early ABA administration was required to increase BDNF expression. Our data suggests that early intervention with ABA can prevent AD, via rescuing IRS1/2 and BDNF expression. | ca_CA |
dc.format.extent | 7 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | IOS Press | ca_CA |
dc.relation.isPartOf | Journal of Alzheimer's Disease Reports, vol. 7, no. 1, pp. 1007-1013, 2023 | ca_CA |
dc.relation.uri | https://dx.doi.org/10.6035/UJI_B201801 | ca_CA |
dc.rights | ISSN 2542-4823 © 2023 – The authors. Published by IOS Press | ca_CA |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | ca_CA |
dc.subject | Alzheimer’s disease | ca_CA |
dc.subject | hippocampus | ca_CA |
dc.subject | insulin signal | ca_CA |
dc.subject | neuroinflammation | ca_CA |
dc.subject | neuroprotector | ca_CA |
dc.subject | neurotrophic factor | ca_CA |
dc.subject | phytohormones | ca_CA |
dc.title | ABA Supplementation Rescues IRS2 and BDNF mRNA Levels in a Triple-Transgenic Mice Model of Alzheimer’s Disease | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.3233/ADR-230056 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
project.funder.name | Universitat Jaume I | ca_CA |
oaire.awardNumber | UJI-B2018-01 | ca_CA |
oaire.awardNumber | UJI-B2021-21 to A.M.S.-P | ca_CA |
dc.subject.ods | 3. Salud y bienestar | ca_CA |
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