ABA Supplementation Rescues IRS2 and BDNF mRNA Levels in a Triple-Transgenic Mice Model of Alzheimer’s Disease
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Título
ABA Supplementation Rescues IRS2 and BDNF mRNA Levels in a Triple-Transgenic Mice Model of Alzheimer’s DiseaseAutoría
Fecha de publicación
2023-09-08Editor
IOS PressISSN
2542-4823Cita bibliográfica
Alves-Borba, Laryssa et al. ‘ABA Supplementation Rescues IRS2 and BDNF mRNA Levels in a Triple-Transgenic Mice Model of Alzheimer’s Disease’. 1 Jan. 2023 : 1007 – 1013.Tipo de documento
info:eu-repo/semantics/articleVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Insulin resistance underlies Alzheimer’s disease (AD) by affecting neuroinflammation and brain-derived neurotrophic factor (BDNF) expression. Here, we evaluated the effect of early and late-start abscisic acid (ABA) ... [+]
Insulin resistance underlies Alzheimer’s disease (AD) by affecting neuroinflammation and brain-derived neurotrophic factor (BDNF) expression. Here, we evaluated the effect of early and late-start abscisic acid (ABA) intervention on hippocampal BDNF, tumor necrosis factor α (TNFα), and insulin receptors substrates (IRS) 1/2 mRNA levels in a triple-transgenic mice model of AD. Transgenic mice displayed lower BDNF and IRS2, equal IRS1, and higher TNFα expression compared to wild-type mice. Late ABA treatment could rescue TNFα and increased IRS1/2 expression. However, early ABA administration was required to increase BDNF expression. Our data suggests that early intervention with ABA can prevent AD, via rescuing IRS1/2 and BDNF expression. [-]
Publicado en
Journal of Alzheimer's Disease Reports, vol. 7, no. 1, pp. 1007-1013, 2023Datos relacionados
https://dx.doi.org/10.6035/UJI_B201801Entidad financiadora
Universitat Jaume I
Código del proyecto o subvención
UJI-B2018-01 | UJI-B2021-21 to A.M.S.-P
Derechos de acceso
ISSN 2542-4823 © 2023 – The authors. Published by IOS Press
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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