Hybrid Endometrial-Derived Hydrogels: Human Organoid Culture Models and In Vivo Perspectives
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Other documents of the author: Gómez-Álvarez, María; Bueno Fernandez, Clara; Rodríguez-Eguren, Adolfo; Francés-Herrero, Emilio; Agustina-Hernández, Marcos; Faus, Amparo; Gisbert Roca, Fernando; Martínez Ramos, Cristina; Galán, Amparo; Pellicer, Antonio; Ferrero, Hortensia; Cervello, Irene
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Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/36080
comunitat-uji-handle3:10234/36082
comunitat-uji-handle4:
INVESTIGACIONMetadata
Title
Hybrid Endometrial-Derived Hydrogels: Human Organoid Culture Models and In Vivo PerspectivesAuthor (s)
Date
2023Publisher
WileyISSN
2192-2640; 2192-2659Bibliographic citation
M. Gómez-Álvarez, C. Bueno-Fernandez, A. Rodríguez-Eguren, E. Francés-Herrero, M. Agustina-Hernández, A. Faus, F. Gisbert Roca, C. Martínez-Ramos, A. Galán, A. Pellicer, H. Ferrero, I. Cervelló, Hybrid Endometrial-Derived Hydrogels: Human Organoid Culture Models and In Vivo Perspectives. Advanced Healthcare Materials, 2024, 13, 11, 2303838. https://doi.org/10.1002/adhm.202303838Type
info:eu-repo/semantics/articlePublisher version
https://onlinelibrary.wiley.com/doi/full/10.1002/adhm.202303838?casa_token=1y9V8 ...Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
The endometrium plays a vital role in fertility, providing a receptive environment for embryo implantation and development. Understanding the endometrial physiology is essential for developing new strategies to improve ... [+]
The endometrium plays a vital role in fertility, providing a receptive environment for embryo implantation and development. Understanding the endometrial physiology is essential for developing new strategies to improve reproductive healthcare. Human endometrial organoids (hEOs) are emerging as powerful models for translational research and personalized medicine. However, most hEOs are cultured in a 3D microenvironment that significantly differs from the human endometrium, limiting their applicability in bioengineering. This study presents a hybrid endometrial-derived hydrogel that combines the rigidity of PuraMatrix (PM) with the natural scaffold components and interactions of a porcine decellularized endometrial extracellular matrix (EndoECM) hydrogel. This hydrogel provides outstanding support for hEO culture, enhances hEO differentiation efficiency due to its biochemical similarity with the native tissue, exhibits superior in vivo stability, and demonstrates xenogeneic biocompatibility in mice over a 2-week period. Taken together, these attributes position this hybrid endometrial-derived hydrogel as a promising biomaterial for regenerative treatments in reproductive medicine. [-]
Is part of
Advanced Healthcare Materials, 2024, 13, 11Funder Name
Instituto de Salud Carlos III | Ministerio de Ciencia, Innovación y Universidades | Generalitat Valenciana | Universitat Politècnica de València
Project code
PI21/00305 | CP20/00120 | CP20/00120 | FPU18/06327 | FPU20/00251 | FPU19/04850 | MS21-142 | CIAPOT/2022/29 | CIPROM/2021/058 | PAID-10-22
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info:eu-repo/semantics/openAccess
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- MED_Articles [662]