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Hybrid Endometrial-Derived Hydrogels: Human Organoid Culture Models and In Vivo Perspectives
dc.contributor.author | Gómez-Álvarez, María | |
dc.contributor.author | Bueno Fernandez, Clara | |
dc.contributor.author | Rodríguez-Eguren, Adolfo | |
dc.contributor.author | Francés-Herrero, Emilio | |
dc.contributor.author | Agustina-Hernández, Marcos | |
dc.contributor.author | Faus, Amparo | |
dc.contributor.author | Gisbert Roca, Fernando | |
dc.contributor.author | Martínez Ramos, Cristina | |
dc.contributor.author | Galán, Amparo | |
dc.contributor.author | Pellicer, Antonio | |
dc.contributor.author | Ferrero, Hortensia | |
dc.contributor.author | Cervello, Irene | |
dc.date.accessioned | 2024-03-15T08:28:04Z | |
dc.date.available | 2024-03-15T08:28:04Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | M. Gómez-Álvarez, C. Bueno-Fernandez, A. Rodríguez-Eguren, E. Francés-Herrero, M. Agustina-Hernández, A. Faus, F. Gisbert Roca, C. Martínez-Ramos, A. Galán, A. Pellicer, H. Ferrero, I. Cervelló, Hybrid Endometrial-Derived Hydrogels: Human Organoid Culture Models and In Vivo Perspectives. Advanced Healthcare Materials, 2024, 13, 11, 2303838. https://doi.org/10.1002/adhm.202303838 | ca_CA |
dc.identifier.issn | 2192-2640 | |
dc.identifier.issn | 2192-2659 | |
dc.identifier.uri | http://hdl.handle.net/10234/206195 | |
dc.description.abstract | The endometrium plays a vital role in fertility, providing a receptive environment for embryo implantation and development. Understanding the endometrial physiology is essential for developing new strategies to improve reproductive healthcare. Human endometrial organoids (hEOs) are emerging as powerful models for translational research and personalized medicine. However, most hEOs are cultured in a 3D microenvironment that significantly differs from the human endometrium, limiting their applicability in bioengineering. This study presents a hybrid endometrial-derived hydrogel that combines the rigidity of PuraMatrix (PM) with the natural scaffold components and interactions of a porcine decellularized endometrial extracellular matrix (EndoECM) hydrogel. This hydrogel provides outstanding support for hEO culture, enhances hEO differentiation efficiency due to its biochemical similarity with the native tissue, exhibits superior in vivo stability, and demonstrates xenogeneic biocompatibility in mice over a 2-week period. Taken together, these attributes position this hybrid endometrial-derived hydrogel as a promising biomaterial for regenerative treatments in reproductive medicine. | ca_CA |
dc.format.extent | 19 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Wiley | ca_CA |
dc.relation.isPartOf | Advanced Healthcare Materials, 2024, 13, 11 | ca_CA |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | ca_CA |
dc.subject | bioengineering | ca_CA |
dc.subject | endometrium | ca_CA |
dc.subject | extracellular matrix hydrogel | ca_CA |
dc.subject | organoids | ca_CA |
dc.title | Hybrid Endometrial-Derived Hydrogels: Human Organoid Culture Models and In Vivo Perspectives | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1002/adhm.202303838 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | https://onlinelibrary.wiley.com/doi/full/10.1002/adhm.202303838?casa_token=1y9V8U648Z4AAAAA%3A5fIci3tVToNqrLSm6W2oXmMeRycFZPFp-5T-Vq4NEaWlz5fqlqelyeBo_Nxpg5Qeps1IwJ6Q4O-kuw | ca_CA |
dc.description.sponsorship | The authors thank Mercavalencia for donating the sow uteri necessary to produce the EndoECM hydrogel, the staff of the animal facilities of the Central Research Unit of the Faculty of Medicine of the University of Valencia, and the scientific team from Hospital Peset for the multiplex analyses. Finally, the authors thank Rosalba Lopez for her editing services in preparing this manuscript for publication. Funding: This work was supported by Instituto de Salud Carlos III and co-founded by the European Union (Fondo Social Europeo), «El FSE invierte en tu futuro» (PI21/00305 [IC]) through the Miguel Servet Program (CP20/00120 [HF]; CP19/00149 [IC]), Ministerio de Universidades (FPU20/00251 [MGÁ], FPU19/04850 [ARE], FPU18/06327 [EFH], MS21-142 [CBF]), Generalitat Valenciana (CIAPOT/2022/29 [MAH], CIPROM/2021/058 [AP and IC]), and Vicerrectorado de Investigación de la Universitat Politècnica de València (PAID-10-22 [FGR]). | |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
project.funder.name | Instituto de Salud Carlos III | ca_CA |
project.funder.name | Ministerio de Ciencia, Innovación y Universidades | ca_CA |
project.funder.name | Generalitat Valenciana | ca_CA |
project.funder.name | Universitat Politècnica de València | ca_CA |
oaire.awardNumber | PI21/00305 | ca_CA |
oaire.awardNumber | CP20/00120 | ca_CA |
oaire.awardNumber | CP20/00120 | ca_CA |
oaire.awardNumber | FPU18/06327 | ca_CA |
oaire.awardNumber | FPU20/00251 | ca_CA |
oaire.awardNumber | FPU19/04850 | ca_CA |
oaire.awardNumber | MS21-142 | ca_CA |
oaire.awardNumber | CIAPOT/2022/29 | ca_CA |
oaire.awardNumber | CIPROM/2021/058 | ca_CA |
oaire.awardNumber | PAID-10-22 | ca_CA |
dc.subject.ods | 3. Salud y bienestar | ca_CA |
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