Characterization of Electrospun BDMC-Loaded PLA Nanofibers with Drug Delivery Function and Anti-Inflammatory Activity
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Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/36080
comunitat-uji-handle3:10234/36082
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INVESTIGACIONMetadata
Title
Characterization of Electrospun BDMC-Loaded PLA Nanofibers with Drug Delivery Function and Anti-Inflammatory ActivityAuthor (s)
Date
2023-06-19Publisher
Multidisciplinary Digital Publishing Institute (MDPI)ISSN
1661-6596Bibliographic citation
Morillo-Bargues MJ, Osorno AO, Guerri C, Pradas MM, Martínez-Ramos C. Characterization of Electrospun BDMC-Loaded PLA Nanofibers with Drug Delivery Function and Anti-Inflammatory Activity. International Journal of Molecular Sciences. 2023; 24(12):10340. https://doi.org/10.3390/ijms241210340.Type
info:eu-repo/semantics/articlePublisher version
https://www.mdpi.com/1422-0067/24/12/10340Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
Controlled drug release systems are the subject of many investigations to achieve the therapeutic effect of drugs. They have numerous advantages, such as localized effects, lower side effects, and less onset of action. ... [+]
Controlled drug release systems are the subject of many investigations to achieve the therapeutic effect of drugs. They have numerous advantages, such as localized effects, lower side effects, and less onset of action. Among drug-delivery systems, electrospinning is a versatile and cost-effective method for biomedical applications. Furthermore, electrospun nanofibers are promising as drug carrier candidates due to their properties that mimic the extracellular matrix. In this work, electrospun fibers were made of Poly-L-lactic acid (PLA), one of the most widely tested materials, which has excellent biocompatible and biodegradable properties. A curcuminoid, bisdemethoxycurcumin (BDMC) was added in order to complete the drug delivery system. The PLA/BDMC membranes were characterized, and biological characteristics were examined in vitro. The results show that the average fiber diameter was reduced with the drug, which was mainly released during the first 24 h by a diffusion mechanism. It was seen that the use of our membranes loaded with BDMC enhanced the rate of proliferation in Schwann cells, the main peripheral neuroglial cells, and modulated inflammation by reducing NLRP3 inflammasome activation. Considering the results, the prepared PLA/BDMC membranes hold great potential for being used in tissue engineering applications. [-]
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International Journal of Molecular Sciences. 2023; 24(12)Funder Name
RISEUP | Agencia Estatal de Investigación | Ministerio de Universidades | Family Process Institute | European Regional Development Fund
Project code
MCIN/AEI/10.13039/501100011033, PID2021-126612OB-I00 | BES-2016-077551
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© 2023 by the authors.
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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