Characterization of Electrospun BDMC-Loaded PLA Nanofibers with Drug Delivery Function and Anti-Inflammatory Activity
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Título
Characterization of Electrospun BDMC-Loaded PLA Nanofibers with Drug Delivery Function and Anti-Inflammatory ActivityAutoría
Fecha de publicación
2023-06-19Editor
Multidisciplinary Digital Publishing Institute (MDPI)ISSN
1661-6596Cita bibliográfica
Morillo-Bargues MJ, Osorno AO, Guerri C, Pradas MM, Martínez-Ramos C. Characterization of Electrospun BDMC-Loaded PLA Nanofibers with Drug Delivery Function and Anti-Inflammatory Activity. International Journal of Molecular Sciences. 2023; 24(12):10340. https://doi.org/10.3390/ijms241210340.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.mdpi.com/1422-0067/24/12/10340Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Controlled drug release systems are the subject of many investigations to achieve the therapeutic effect of drugs. They have numerous advantages, such as localized effects, lower side effects, and less onset of action. ... [+]
Controlled drug release systems are the subject of many investigations to achieve the therapeutic effect of drugs. They have numerous advantages, such as localized effects, lower side effects, and less onset of action. Among drug-delivery systems, electrospinning is a versatile and cost-effective method for biomedical applications. Furthermore, electrospun nanofibers are promising as drug carrier candidates due to their properties that mimic the extracellular matrix. In this work, electrospun fibers were made of Poly-L-lactic acid (PLA), one of the most widely tested materials, which has excellent biocompatible and biodegradable properties. A curcuminoid, bisdemethoxycurcumin (BDMC) was added in order to complete the drug delivery system. The PLA/BDMC membranes were characterized, and biological characteristics were examined in vitro. The results show that the average fiber diameter was reduced with the drug, which was mainly released during the first 24 h by a diffusion mechanism. It was seen that the use of our membranes loaded with BDMC enhanced the rate of proliferation in Schwann cells, the main peripheral neuroglial cells, and modulated inflammation by reducing NLRP3 inflammasome activation. Considering the results, the prepared PLA/BDMC membranes hold great potential for being used in tissue engineering applications. [-]
Publicado en
International Journal of Molecular Sciences. 2023; 24(12)Entidad financiadora
RISEUP | Agencia Estatal de Investigación | Ministerio de Universidades | Family Process Institute | European Regional Development Fund
Código del proyecto o subvención
MCIN/AEI/10.13039/501100011033, PID2021-126612OB-I00 | BES-2016-077551
Derechos de acceso
© 2023 by the authors.
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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