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Pre-training working memory/information processing capabilities and brain atrophy limit the improving effects of cognitive training
dc.contributor.author | Félix Esbrí, Sónia | |
dc.contributor.author | Sebastián Tirado, Alba | |
dc.contributor.author | Zaragoza Mezquita, María | |
dc.contributor.author | Sanchis-Segura, Carla | |
dc.contributor.author | Forn, Cristina | |
dc.date.accessioned | 2023-09-14T09:35:53Z | |
dc.date.available | 2023-09-14T09:35:53Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | ESBRÍ, Sónia Félix, et al. Pre-training working memory/information processing capabilities and brain atrophy limit the improving effects of cognitive training. Multiple Sclerosis Journal–Experimental, Translational and Clinical, 2023, vol. 9, no 3, p. 20552173231196990. | ca_CA |
dc.identifier.uri | http://hdl.handle.net/10234/204174 | |
dc.description.abstract | Background: Computerized training in persons with multiple sclerosis (PwMS) seems to enhance working memory (WM)/information processing (IP), but factors associated with the efficacy of the treatment have not been sufficiently explored. Objective: To identify clinical and radiological characteristics associated with positive WM/IP training responses. Methods: Radiological and neuropsychological assessments were carried out on a sample of 35 PwMs who were divided into “WM/IP-impaired” and “WM/IP-preserved.” All participants underwent adaptive n-back training for 10 days and were assessed post-training. Between-group differences (“WM/IPimpaired” vs. “WM/IP-preserved”) in training-induced cognitive improvement were assessed and exploratory correlational/ regression-based methods were employed to assess the relationship between cognitive improvement and clinical and radiological variables. Results: All PwMS exhibited WM/IP benefits after training, but those with preserved WM/IP functions showed greater positive effects as well as transfer effects to other WM/IP tests when compared to the impaired group. Additional analyses revealed that positive response to treatment was associated with WM/IP baseline capabilities and greater gray matter volume (GMVOL) in relevant areas such as the thalamus. Conclusions: Restorative cognitive training is suitable to improve cognition in PwMS but its effective outcome differs depending on the baseline WM/IP capabilities and GMVOL. | ca_CA |
dc.format.extent | 12 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Sage | ca_CA |
dc.relation.isPartOf | MSJ Experimental, Translational and Clinical, 2023 | ca_CA |
dc.rights | © The Author(s), 2023. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). | ca_CA |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | ca_CA |
dc.subject | Multiple sclerosis | ca_CA |
dc.subject | cognitive training | ca_CA |
dc.subject | working memory | ca_CA |
dc.subject | transfer effects brain atrophy | ca_CA |
dc.subject | treatment response | ca_CA |
dc.title | Pre-training working memory/information processing capabilities and brain atrophy limit the improving effects of cognitive training | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1177/20552173231196990 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | https://journals.sagepub.com/doi/epub/10.1177/20552173231196990 | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
project.funder.name | Universitat Jaume I | ca_CA |
project.funder.name | Ministerio de Ciencia e Innovación | ca_CA |
oaire.awardNumber | PREDOC/2020/22 | ca_CA |
oaire.awardNumber | UJI B2020-02 | ca_CA |
oaire.awardNumber | MCI/AEI 10.13039/ 501100011033 | ca_CA |
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Except where otherwise noted, this item's license is described as © The Author(s), 2023. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0
License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further
permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).