Pre-training working memory/information processing capabilities and brain atrophy limit the improving effects of cognitive training
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Título
Pre-training working memory/information processing capabilities and brain atrophy limit the improving effects of cognitive trainingAutoría
Fecha de publicación
2023Editor
SageCita bibliográfica
ESBRÍ, Sónia Félix, et al. Pre-training working memory/information processing capabilities and brain atrophy limit the improving effects of cognitive training. Multiple Sclerosis Journal–Experimental, Translational and Clinical, 2023, vol. 9, no 3, p. 20552173231196990.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://journals.sagepub.com/doi/epub/10.1177/20552173231196990Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Background: Computerized training in persons with multiple sclerosis (PwMS) seems to enhance
working memory (WM)/information processing (IP), but factors associated with the efficacy of the treatment have not been ... [+]
Background: Computerized training in persons with multiple sclerosis (PwMS) seems to enhance
working memory (WM)/information processing (IP), but factors associated with the efficacy of the treatment have not been sufficiently explored. Objective: To identify clinical and radiological characteristics
associated with positive WM/IP training responses.
Methods: Radiological and neuropsychological assessments were carried out on a sample of 35 PwMs
who were divided into “WM/IP-impaired” and “WM/IP-preserved.” All participants underwent adaptive
n-back training for 10 days and were assessed post-training. Between-group differences (“WM/IPimpaired” vs. “WM/IP-preserved”) in training-induced cognitive improvement were assessed and exploratory correlational/ regression-based methods were employed to assess the relationship between cognitive
improvement and clinical and radiological variables.
Results: All PwMS exhibited WM/IP benefits after training, but those with preserved WM/IP functions
showed greater positive effects as well as transfer effects to other WM/IP tests when compared to the impaired
group. Additional analyses revealed that positive response to treatment was associated with WM/IP baseline
capabilities and greater gray matter volume (GMVOL) in relevant areas such as the thalamus.
Conclusions: Restorative cognitive training is suitable to improve cognition in PwMS but its effective
outcome differs depending on the baseline WM/IP capabilities and GMVOL. [-]
Publicado en
MSJ Experimental, Translational and Clinical, 2023Entidad financiadora
Universitat Jaume I | Ministerio de Ciencia e Innovación
Código del proyecto o subvención
PREDOC/2020/22 | UJI B2020-02 | MCI/AEI 10.13039/ 501100011033
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info:eu-repo/semantics/openAccess
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Excepto si se señala otra cosa, la licencia del ítem se describe como: © The Author(s), 2023. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0
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