Home-based transcranial direct current stimulation in mild neurocognitive disorder due to possible Alzheimer's disease. A randomised, single-blind, controlled-placebo study
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Altres documents de l'autoria: Satorres, Encarnacion; Escudero Torrella, Joaquin; Real, Elena; Pitarque, Alfonso; Delhom, Iraida; Melendez, Juan C
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Home-based transcranial direct current stimulation in mild neurocognitive disorder due to possible Alzheimer's disease. A randomised, single-blind, controlled-placebo studyAutoria
Data de publicació
2023Editor
Frontiers MediaISSN
1664-1078Cita bibliogràfica
Satorres E, Escudero Torrella J, Real E, Pitarque A, Delhom I and Melendez JC (2023) Home-based transcranial direct current stimulation in mild neurocognitive disorder due to possible Alzheimer’s disease. A randomised, single-blind, controlled-placebo study. Front. Psychol. 13:1071737. doi: 10.3389/fpsyg.2022.1071737Tipus de document
info:eu-repo/semantics/articleVersió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
Introduction: Mild neurocognitive disorder (mNCD), a pre-dementia stage
close to Mild Cognitive Impairment, shows a progressive and constant
decline in the memory domain. Of the non-pharmacological therapeutic
in ... [+]
Introduction: Mild neurocognitive disorder (mNCD), a pre-dementia stage
close to Mild Cognitive Impairment, shows a progressive and constant
decline in the memory domain. Of the non-pharmacological therapeutic
interventions that may help to decelerate the neurodegenerative progress,
transcranial direct current stimulation (tDCS) shows beneficial effects on the
learning curve, immediate recall, immediate verbal memory and executive
functions. The purpose of this research was to study the effect of tDCS on
general cognition, immediate and delayed memory and executive functions
by comparing an active group with a placebo group of mNCD patients.
Methods: Participants were 33 mNCD due to possible AD, randomly
assigned to two groups: 17 active tDCS and 16 placebo tDCS. Ten sessions
of tDCS were conducted over the left dorsolateral prefrontal cortex. Several
neuropsychological scales were administered to assess the primary outcome
measures of general cognitive function, immediate and delayed memory and
learning ability, whereas the secondary outcome measures included executive
function tests. All participants were evaluated at baseline and at the end of the
intervention. Mixed ANOVAs were performed.
Results: Significant effects were obtained on general cognitive function,
immediate and delayed memory and learning ability, with increases in scores
in the active tDCS group. However, there were no significant effects on
executive function performance.
Conclusion: The present study demonstrated the effectiveness of tDCS in
an active tDCS group, compared to a placebo group, in improving general
cognition and immediate and delayed memory, as previous studies found.
Taken together, our data suggest that tDCS is a simple, painless, reproducible
and easy technique that is useful for treating cognitive alterations found in
neurodegenerative diseases. [-]
Publicat a
Frontiers in Psychology, 13:1071737Entitat finançadora
Ministerio de Ciencia e Innovación (MCIN)/Agencia Estatal de Investigación | Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital of Generalitat Valenciana
Codi del projecte o subvenció
(AEI)/10.13039/501100011033 | PID2019-103956RB-I00 | GV/2021/174
Drets d'accés
info:eu-repo/semantics/openAccess
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