Rapid encoding of task regularities in the human hippocampus guides sensorimotor timing
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Otros documentos de la autoría: Polti, Ignacio; Nau, Matthias; Kaplan, Raphael; van Wassenhove, Virginie; Doeller, Christian
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Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/8636
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Título
Rapid encoding of task regularities in the human hippocampus guides sensorimotor timingAutoría
Fecha de publicación
2022-11-01Editor
eLife Sciences PublicationsCita bibliográfica
POLTI, Ignacio, et al. Rapid encoding of task regularities in the human hippocampus guides sensorimotor timing. Elife, 2022, vol. 11, p. e79027.Tipo de documento
info:eu-repo/semantics/articleVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
The brain encodes the statistical regularities of the environment in a task-specific yet flexible and generalizable format. Here, we seek to understand this process by bridging two parallel lines of research, one ... [+]
The brain encodes the statistical regularities of the environment in a task-specific yet flexible and generalizable format. Here, we seek to understand this process by bridging two parallel lines of research, one centered on sensorimotor timing, and the other on cognitive mapping in the hippocampal system. By combining functional magnetic resonance imaging (fMRI) with a fast-paced time-to-contact (TTC) estimation task, we found that the hippocampus signaled behavioral feedback received in each trial as well as performance improvements across trials along with reward-processing regions. Critically, it signaled performance improvements independent from the tested intervals, and its activity accounted for the trial-wise regression-to-the-mean biases in TTC estimation. This is in line with the idea that the hippocampus supports the rapid encoding of temporal context even on short time scales in a behavior-dependent manner. Our results emphasize the central role of the hippocampus in statistical learning and position it at the core of a brain-wide network updating sensorimotor representations in real time for flexible behavior. [-]
Publicado en
Elife, 2022, vol. 11Entidad financiadora
European Research Council (ERC) | Max Planck Society | Kavli Foundation | Kristian Gerhard Jebsen Foundation | Norges Forskningsråd | Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits | Alexander von Humboldt Foundation | Generalitat Valenciana | Ministerio de Ciencia, Innovación y Universidades (Spain) | Commissariat à l'Énergie Atomique et aux Énergies Alternatives | Institut National de la Santé et de la Recherche Médicale
Código del proyecto o subvención
ERC-CoG GEOCOG 724836 | 223262/F50 | NORBRAIN 197467/F50 | Feodor-Lynen Research Fellowship | CIDEGENT/2021/027 | PID2021-122338NA-I00
Derechos de acceso
Copyright Polti, Nau et al
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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