Rapid encoding of task regularities in the human hippocampus guides sensorimotor timing
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Títol
Rapid encoding of task regularities in the human hippocampus guides sensorimotor timingAutoria
Data de publicació
2022-11-01Editor
eLife Sciences PublicationsCita bibliogràfica
POLTI, Ignacio, et al. Rapid encoding of task regularities in the human hippocampus guides sensorimotor timing. Elife, 2022, vol. 11, p. e79027.Tipus de document
info:eu-repo/semantics/articleVersió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
The brain encodes the statistical regularities of the environment in a task-specific yet flexible and generalizable format. Here, we seek to understand this process by bridging two parallel lines of research, one ... [+]
The brain encodes the statistical regularities of the environment in a task-specific yet flexible and generalizable format. Here, we seek to understand this process by bridging two parallel lines of research, one centered on sensorimotor timing, and the other on cognitive mapping in the hippocampal system. By combining functional magnetic resonance imaging (fMRI) with a fast-paced time-to-contact (TTC) estimation task, we found that the hippocampus signaled behavioral feedback received in each trial as well as performance improvements across trials along with reward-processing regions. Critically, it signaled performance improvements independent from the tested intervals, and its activity accounted for the trial-wise regression-to-the-mean biases in TTC estimation. This is in line with the idea that the hippocampus supports the rapid encoding of temporal context even on short time scales in a behavior-dependent manner. Our results emphasize the central role of the hippocampus in statistical learning and position it at the core of a brain-wide network updating sensorimotor representations in real time for flexible behavior. [-]
Publicat a
Elife, 2022, vol. 11Entitat finançadora
European Research Council (ERC) | Max Planck Society | Kavli Foundation | Kristian Gerhard Jebsen Foundation | Norges Forskningsråd | Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits | Alexander von Humboldt Foundation | Generalitat Valenciana | Ministerio de Ciencia, Innovación y Universidades (Spain) | Commissariat à l'Énergie Atomique et aux Énergies Alternatives | Institut National de la Santé et de la Recherche Médicale
Codi del projecte o subvenció
ERC-CoG GEOCOG 724836 | 223262/F50 | NORBRAIN 197467/F50 | Feodor-Lynen Research Fellowship | CIDEGENT/2021/027 | PID2021-122338NA-I00
Drets d'accés
Copyright Polti, Nau et al
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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