Mostrar el registro sencillo del ítem
Benefits of Ion Mobility Separation in GC-APCI-HRMS Screening: From the Construction of a CCS Library to the Application to Real-World Samples
dc.contributor.author | Izquierdo-Sandoval, David | |
dc.contributor.author | Fabregat-Safont, David | |
dc.contributor.author | Lacalle-Bergeron, Leticia | |
dc.contributor.author | Sancho, Juan V | |
dc.contributor.author | Hernandez, Felix | |
dc.contributor.author | Portoles, Tania | |
dc.date.accessioned | 2022-10-18T11:59:00Z | |
dc.date.available | 2022-10-18T11:59:00Z | |
dc.date.issued | 2022-06-28 | |
dc.identifier.citation | Izquierdo-Sandoval, D., Fabregat-Safont, D., Lacalle-Bergeron, L., Sancho, J. V., Hernández, F., Portoles, T. Benefits of Ion Mobility Separation in GC-APCI-HRMS Screening: From the Construction of a CCS Library to the Application to Real-World Samples. Anal. Chem. 2022, 94, 25, 9040-9047, DOI: 10.1021/acs.analchem.2c01118 | ca_CA |
dc.identifier.issn | 0003-2700 | |
dc.identifier.issn | 1520-6882 | |
dc.identifier.uri | http://hdl.handle.net/10234/200442 | |
dc.description.abstract | The performance of gas chromatography (GC) combined with the improved identification properties of ion mobility separation coupled to high-resolution mass spectrometry (IMS-HRMS) is presented as a promising approach for the monitoring of (semi)volatile compounds in complex matrices. The soft ionization promoted by an atmospheric pressure chemical ionization (APCI) source designed for GC preserves the molecular and/or quasi-molecular ion information enabling a rapid, sensitive, and efficient wide-scope screening. Additionally, ion mobility separation (IMS) separates species of interest from coeluting matrix interferences and/or resolves isomers based on their charge, shape, and size, making IMS-derived collision cross section (CCS) a robust and matrix-independent parameter comparable between instruments. In this way, GC-APCI-IMS-HRMS becomes a powerful approach for both target and suspect screening due to the improvements in (tentative) identifications. In this work, mobility data for 264 relevant multiclass organic pollutants in environmental and food-safety fields were collected by coupling GC-APCI with IMS-HRMS, generating CCS information for molecular ion and/or protonated molecules and some in-source fragments. The identification power of GC-APCI-IMS-HRMS for the studied compounds was assessed in complex-matrix samples, including fish feed extracts, surface waters, and different fruit and vegetable samples. | ca_CA |
dc.format.extent | 8 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | American Chemical Society | ca_CA |
dc.relation.isPartOf | Analytical Chemistry, 2022, vol. 94, no 25 | ca_CA |
dc.rights | Copyright © American Chemical Society | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/CNE/1.0/ | ca_CA |
dc.subject | chromatography | ca_CA |
dc.subject | ionization | ca_CA |
dc.subject | ions | ca_CA |
dc.subject | molecules | ca_CA |
dc.subject | reaction mechanisms | ca_CA |
dc.title | Benefits of Ion Mobility Separation in GC-APCI-HRMS Screening: From the Construction of a CCS Library to the Application to Real-World Samples | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1021/acs.analchem.2c01118 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | https://pubs.acs.org/doi/full/10.1021/acs.analchem.2c01118 | ca_CA |
dc.description.sponsorship | D.I.-S. acknowledges the Ministry of Education and Vocational Training of Spain for funding his research through the FPU pre-doctoral program (FPU19/01839). T.P. acknowledges Ramon y Cajal Program from the Ministry of Economy and Competitiveness of Spain (RYC-2017-22525) for funding her research. This work received financial support from the University Jaume I (UJI-B2020-37). We are grateful with the professor Daniel A. Burgard from University of Puget Sound for his diligent comments and proofreading of this manuscript. | |
dc.type.version | info:eu-repo/semantics/submittedVersion | ca_CA |
project.funder.name | Ministerio de Educación y Formación Profesional | ca_CA |
project.funder.name | Ministerio de Economía y Competitividad | ca_CA |
project.funder.name | Universitat Jaume I | ca_CA |
oaire.awardNumber | FPU19/01839 | ca_CA |
oaire.awardNumber | RYC-2017-22525 | ca_CA |
oaire.awardNumber | UJI-B2020-37 | ca_CA |
Ficheros en el ítem
Este ítem aparece en la(s) siguiente(s) colección(ones)
-
IUPA_Articles [310]