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dc.contributor.authorBlasco-Lafarga, Cristina
dc.contributor.authorMonferrer-Marín, Jordi
dc.contributor.authorRoldán, Ainoa
dc.contributor.authorMonteagudo, Pablo
dc.contributor.authorChulvi-Medrano, Iván
dc.date.accessioned2022-09-19T14:22:31Z
dc.date.available2022-09-19T14:22:31Z
dc.date.issued2022
dc.identifier.citationBlasco-Lafarga C, Monferrer-Marín J, Roldán A, Monteagudo P and Chulvi-Medrano I (2022) Metabolic Flexibility and Mechanical Efficiency in Women Over-60. Front. Physiol. 13:869534. doi: 10.3389/fphys.2022.869534ca_CA
dc.identifier.issn1664-042X
dc.identifier.urihttp://hdl.handle.net/10234/199651
dc.description.abstractPurpose: Aging deteriorates metabolic flexibility (MF). Moreover, recent studies show that glycolysis is barely increased despite impoverished lipid metabolism, in addition to increased relevance of muscle power in older adults. This study aims to analyze MF, i.e., fat and carbohydrates oxidation rates (FATox and CHOox), and the point of maximal fat oxidation (MFO), in a group of active women over-60. It also aims to delve into the role of power production and mechanical efficiency regarding MF. This will help to decipher their metabolic behavior in response to increasing intensity. Methods: Twenty-nine women (66.13 ± 5.62 years) performed a submaximal graded cycling test, increasing 10 W each 3-min15-s, from 30 W to the second ventilatory threshold (VT2). Muscle power was adjusted with a Saris-H3 roller, together with a continuous gas analysis by indirect calorimetry (Cosmed K4b2). Pre and post-test blood lactate (BLa) samples were included. Frayn’s equations, MFO and CHOoxpeak (mg/min/kg FFM) were considered for MF analysis (accounting for average VO2 and VCO2 in each last 60-s), whilst delta and gross efficiencies (DE%, GE%), and exercise economy (EC), were added for Mechanical Efficiency. Mean comparisons regarding intensities 60, 80 and 100% at VT2, completed the study together with correlation analysis among the main variables. Results: MFO and CHOoxpeak were small (6.35 ± 3.59 and 72.79 ± 34.76 g/min/kgFFM respectively) for a reduced muscle power (78.21 ± 15.84 W). Notwithstanding, GE% and EC increased significantly (p < 0.01) with exercise intensity. Importantly, coefficients of variation were very large confirming heterogeneity. Whilst muscle power outcomes correlated significantly (p < 0.01) with MFO (r = 0.66) and age (r = −0.62), these latter failed to be associated. Only GE% correlated to CHOoxpeak (r = −0.61, p < 0.01) regarding mechanical efficiency. Conclusions: Despite being active, women over-60 confirmed impaired substrates switching in response to exercise, from both FAT and CHO pathways. This limits their power production affecting exercise capacity. Our data suggest that decreased power with age has a key role above age per se in this metabolic inflexibility. Vice versa, increasing power seems to protect from mitochondrial dysfunction with aging. New studies will confirm if this higher efficiency when coming close to VT2, where GE is the more informative variable, might be a protective compensatory mechanism.ca_CA
dc.format.extent11 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherFrontiers Mediaca_CA
dc.relation.isPartOfFrontiers in Physiology, 13:869534ca_CA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/ca_CA
dc.subjectagingca_CA
dc.subjectcardiovascular healthca_CA
dc.subjectexercise economyca_CA
dc.subjectgross efficiencyca_CA
dc.subjectmuscle powerca_CA
dc.subjectphysical exerciseca_CA
dc.titleMetabolic flexibility and mechanical efficiency in women over-60ca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttps://doi.org/10.3389/fphys.2022.869534
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_CA
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_CA
project.funder.nameMinistry of Education and Vocational Trainingca_CA
oaire.awardNumber2021/2022 (21CO1/007096)ca_CA


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