Metabolic flexibility and mechanical efficiency in women over-60
Ver/ Abrir
Impacto
Scholar |
Otros documentos de la autoría: Blasco-Lafarga, Cristina; Monferrer-Marín, Jordi; Roldán, Ainoa; Monteagudo, Pablo; Chulvi-Medrano, Iván
Metadatos
Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/174799
comunitat-uji-handle3:10234/174800
comunitat-uji-handle4:
INVESTIGACIONMetadatos
Título
Metabolic flexibility and mechanical efficiency in women over-60Autoría
Fecha de publicación
2022Editor
Frontiers MediaISSN
1664-042XCita bibliográfica
Blasco-Lafarga C, Monferrer-Marín J, Roldán A, Monteagudo P and Chulvi-Medrano I (2022) Metabolic Flexibility and Mechanical Efficiency in Women Over-60. Front. Physiol. 13:869534. doi: 10.3389/fphys.2022.869534Tipo de documento
info:eu-repo/semantics/articleVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Purpose: Aging deteriorates metabolic flexibility (MF). Moreover, recent studies show that glycolysis is barely increased despite impoverished lipid metabolism, in addition to increased relevance of muscle power in ... [+]
Purpose: Aging deteriorates metabolic flexibility (MF). Moreover, recent studies show that glycolysis is barely increased despite impoverished lipid metabolism, in addition to increased relevance of muscle power in older adults. This study aims to analyze MF, i.e., fat and carbohydrates oxidation rates (FATox and CHOox), and the point of maximal fat oxidation (MFO), in a group of active women over-60. It also aims to delve into the role of power production and mechanical efficiency regarding MF. This will help to decipher their metabolic behavior in response to increasing intensity.
Methods: Twenty-nine women (66.13 ± 5.62 years) performed a submaximal graded cycling test, increasing 10 W each 3-min15-s, from 30 W to the second ventilatory threshold (VT2). Muscle power was adjusted with a Saris-H3 roller, together with a continuous gas analysis by indirect calorimetry (Cosmed K4b2). Pre and post-test blood lactate (BLa) samples were included. Frayn’s equations, MFO and CHOoxpeak (mg/min/kg FFM) were considered for MF analysis (accounting for average VO2 and VCO2 in each last 60-s), whilst delta and gross efficiencies (DE%, GE%), and exercise economy (EC), were added for Mechanical Efficiency. Mean comparisons regarding intensities 60, 80 and 100% at VT2, completed the study together with correlation analysis among the main variables.
Results: MFO and CHOoxpeak were small (6.35 ± 3.59 and 72.79 ± 34.76 g/min/kgFFM respectively) for a reduced muscle power (78.21 ± 15.84 W). Notwithstanding, GE% and EC increased significantly (p < 0.01) with exercise intensity. Importantly, coefficients of variation were very large confirming heterogeneity. Whilst muscle power outcomes correlated significantly (p < 0.01) with MFO (r = 0.66) and age (r = −0.62), these latter failed to be associated. Only GE% correlated to CHOoxpeak (r = −0.61, p < 0.01) regarding mechanical efficiency.
Conclusions: Despite being active, women over-60 confirmed impaired substrates switching in response to exercise, from both FAT and CHO pathways. This limits their power production affecting exercise capacity. Our data suggest that decreased power with age has a key role above age per se in this metabolic inflexibility. Vice versa, increasing power seems to protect from mitochondrial dysfunction with aging. New studies will confirm if this higher efficiency when coming close to VT2, where GE is the more informative variable, might be a protective compensatory mechanism. [-]
Publicado en
Frontiers in Physiology, 13:869534Entidad financiadora
Ministry of Education and Vocational Training
Código del proyecto o subvención
2021/2022 (21CO1/007096)
Derechos de acceso
info:eu-repo/semantics/openAccess
Aparece en las colecciones
- EDE_Articles [420]