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dc.contributor.authorCompañ, Vicente
dc.contributor.authorAguilella-Arzo, Marcel
dc.contributor.authordel Castillo, Roxana
dc.contributor.authorEspinós Gutiérrez, Francisco J.
dc.contributor.authordel Castillo, Luis Felipe
dc.date.accessioned2022-07-22T10:50:30Z
dc.date.available2022-07-22T10:50:30Z
dc.date.issued2021-02-13
dc.identifier.citationMoreno, V. C., Aguilella-Arzo, M., Del Castillo, R. M., Espinós, F. J., & Del Castillo, L. F. (2022). A refined model on flow and oxygen consumption in the human cornea depending on the oxygen tension at the interface cornea/post lens tear film during contact lens wear. Journal of Optometry, 15(2), 160-174.ca_CA
dc.identifier.issn1888-4296
dc.identifier.issn1989-1342
dc.identifier.urihttp://hdl.handle.net/10234/198678
dc.description.abstractThe study of oxygen consumption rate under” in vivo” human cornea during contact lens wear has been technically a challenge and several attempts have been made in the last 20 years to model the physiology of the human cornea during contact lens wear. Unfortunately, some of these models, based on a constant corneal oxygen consumption rate, produce areas on the cornea where the oxygen tension is negative, which has no physical sense. In order to avoid such inconsistency, different researchers have developed alternative models of oxygen consumption, which predict the likely oxygen metrics available at the interface cornea/post lens tear film by determination of oxygen flux, oxygen consumption, and oxygen tension through the different layers (endothelium, stroma, and epithelium). Although oxygen deficiency produces corneal edema, corneal swelling, hypoxia, acidosis, and other abnormalities, the estimation of the oxygen distribution below the impact of a contact lens wear is interesting to know which lens transmissibility was adequate to maintain the cornea and avoid epithelial and stromal anoxia. The estimation of minimum transmissibility for a lens for extended wear applications will be very useful for both clinicians and manufacturers. The aim of this work is to present a complete discussion based on Monod kinetics model that permits give an estimation of oxygen partial pressure distribution, the profile distribution of corneal flux and oxygen consumption rate, and finally the estimation of the relaxation mechanism of the cornea depending on the oxygen tension at the interface cornea/post lens tear film. Relaxation time in this context can quantify the capability of the corneal tissue to adapt to increasing concentrations of oxygen. It is proposed this parameter as a biological meaningful indicator of the interaction between contact lens polymers and living tissues such as the corneal cellular layer.ca_CA
dc.format.extent15 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherElsevierca_CA
dc.relation.isPartOfJournal of Optometry. Volume 15, Issue 2, April–June 2022, Pages 160-174ca_CA
dc.rights1888-4296/© 2021 Spanish General Council of Optometry. Published by Elsevier Espana, ˜ S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).ca_CA
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/ca_CA
dc.subjectcontact lensca_CA
dc.subjecttear filmca_CA
dc.subjectcorneaca_CA
dc.subjectOxygen consumption rateca_CA
dc.subjectOxygen fluxca_CA
dc.subjectOxygen tensionca_CA
dc.subjectcorneal hypoxiaca_CA
dc.subjectmonod kinetics modelca_CA
dc.titleA refined model on flow and oxygen consumption in the human cornea depending on the oxygen tension at the interface cornea/post lens tear film during contact lens wearca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttps://doi.org/10.1016/j.optom.2020.12.002
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_CA
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_CA
project.funder.nameGobierno de Españaca_CA
project.funder.nameUniversitat Jaume Ica_CA
project.funder.nameUNAM-PAPIITca_CA
oaire.awardNumberPID2019-108434GB-100 AEI/FEDER,UEca_CA
oaire.awardNumberUJI-B2018-53ca_CA
oaire.awardNumberIG 100618ca_CA
oaire.awardNumberIG 114818ca_CA
oaire.awardNumberIN114318ca_CA
oaire.awardNumberIN120120ca_CA


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1888-4296/© 2021 Spanish General Council of Optometry. Published by Elsevier Espana, ˜ S.L.U. This is an open access article under the CC
BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Excepto si se señala otra cosa, la licencia del ítem se describe como: 1888-4296/© 2021 Spanish General Council of Optometry. Published by Elsevier Espana, ˜ S.L.U. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).