A refined model on flow and oxygen consumption in the human cornea depending on the oxygen tension at the interface cornea/post lens tear film during contact lens wear
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Título
A refined model on flow and oxygen consumption in the human cornea depending on the oxygen tension at the interface cornea/post lens tear film during contact lens wearAutoría
Fecha de publicación
2021-02-13Editor
ElsevierISSN
1888-4296; 1989-1342Cita bibliográfica
Moreno, V. C., Aguilella-Arzo, M., Del Castillo, R. M., Espinós, F. J., & Del Castillo, L. F. (2022). A refined model on flow and oxygen consumption in the human cornea depending on the oxygen tension at the interface cornea/post lens tear film during contact lens wear. Journal of Optometry, 15(2), 160-174.Tipo de documento
info:eu-repo/semantics/articleVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
The study of oxygen consumption rate under” in vivo” human cornea during contact lens wear has been technically a challenge and several attempts have been made in the last 20 years to model the physiology of the human ... [+]
The study of oxygen consumption rate under” in vivo” human cornea during contact lens wear has been technically a challenge and several attempts have been made in the last 20 years to model the physiology of the human cornea during contact lens wear. Unfortunately, some of these models, based on a constant corneal oxygen consumption rate, produce areas on the cornea where the oxygen tension is negative, which has no physical sense. In order to avoid such inconsistency, different researchers have developed alternative models of oxygen consumption, which predict the likely oxygen metrics available at the interface cornea/post lens tear film by determination of oxygen flux, oxygen consumption, and oxygen tension through the different layers (endothelium, stroma, and epithelium). Although oxygen deficiency produces corneal edema, corneal swelling, hypoxia, acidosis, and other abnormalities, the estimation of the oxygen distribution below the impact of a contact lens wear is interesting to know which lens transmissibility was adequate to maintain the cornea and avoid epithelial and stromal anoxia. The estimation of minimum transmissibility for a lens for extended wear applications will be very useful for both clinicians and manufacturers. The aim of this work is to present a complete discussion based on Monod kinetics model that permits give an estimation of oxygen partial pressure distribution, the profile distribution of corneal flux and oxygen consumption rate, and finally the estimation of the relaxation mechanism of the cornea depending on the oxygen tension at the interface cornea/post lens tear film. Relaxation time in this context can quantify the capability of the corneal tissue to adapt to increasing concentrations of oxygen. It is proposed this parameter as a biological meaningful indicator of the interaction between contact lens polymers and living tissues such as the corneal cellular layer. [-]
Publicado en
Journal of Optometry. Volume 15, Issue 2, April–June 2022, Pages 160-174Entidad financiadora
Gobierno de España | Universitat Jaume I | UNAM-PAPIIT
Código del proyecto o subvención
PID2019-108434GB-100 AEI/FEDER,UE | UJI-B2018-53 | IG 100618 | IG 114818 | IN114318 | IN120120
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info:eu-repo/semantics/openAccess
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Excepto si se señala otra cosa, la licencia del ítem se describe como: 1888-4296/© 2021 Spanish General Council of Optometry. Published by Elsevier Espana, ˜ S.L.U. This is an open access article under the CC
BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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