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Glutathione-responsive molecular nanoparticles from a dianionic bolaamphiphile and their use as carriers for targeted delivery
dc.contributor.author | Navarro Barreda, Diego | |
dc.contributor.author | Bedrina Broch, Begoña | |
dc.contributor.author | Galindo, Francisco | |
dc.contributor.author | Miravet, Juan | |
dc.date.accessioned | 2022-05-02T07:46:10Z | |
dc.date.available | 2022-05-02T07:46:10Z | |
dc.date.issued | 2021-11-06 | |
dc.identifier.citation | Navarro-Barreda, D., Bedrina, B., Galindo, F., & Miravet, J. F. (2022). Glutathione-responsive molecular nanoparticles from a dianionic bolaamphiphile and their use as carriers for targeted delivery. Journal of Colloid and Interface Science, 608, 2009-2017. | ca_CA |
dc.identifier.issn | 0021-9797 | |
dc.identifier.uri | http://hdl.handle.net/10234/197421 | |
dc.description.abstract | The formation in aqueous media of molecular nanoparticles from a bolaamphiphile (SucIleCsa) incorporating a disulfide moiety is described. The particles can be loaded efficiently with the lipophilic mitochondrial marker DiOC6(3), quenching its fluorescence, which is recovered upon reductive particle disassembly. DiOC6(3) transport into human colorectal adenocarcinoma cells (HT-29) is demonstrated using flow cytometry and confocal scanning fluorescence microscopy. A significant increase in intracellular fluorescence is observed when the cells are stimulated to produce glutathione (GSH). These new molecular nanoparticles can be considered a theranostic tool that simultaneously achieves targeted delivery of lipophilic substances and signals high levels of GSH. | ca_CA |
dc.format.extent | 9 p. | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Elsevier | ca_CA |
dc.relation.isPartOf | ournal of Colloid and Interface Science 608 (2022) 2009–2017 | ca_CA |
dc.relation.uri | https://ars.els-cdn.com/content/image/1-s2.0-S0021979721018154-mmc1.docx | ca_CA |
dc.rights | ©2021 Elsevier Inc. All rights reserved. | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | ca_CA |
dc.subject | nanocarrier | ca_CA |
dc.subject | self-assembly | ca_CA |
dc.subject | amphiphile | ca_CA |
dc.subject | glutathione-responsive | ca_CA |
dc.title | Glutathione-responsive molecular nanoparticles from a dianionic bolaamphiphile and their use as carriers for targeted delivery | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1016/j.jcis.2021.10.142 | |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
project.funder.name | Ministerio de Ciencia, Innovación y Universidades (Spain) | ca_CA |
project.funder.name | European Regional Development Fund | ca_CA |
project.funder.name | FISABIO | ca_CA |
project.funder.name | Generalitat Valenciana | ca_CA |
project.funder.name | Universitat Jaume I | ca_CA |
oaire.awardNumber | RTI2018-096748-B-I00 | ca_CA |
oaire.awardNumber | UGP-19-033 | ca_CA |
oaire.awardNumber | AICO/2020/322 | ca_CA |
oaire.awardNumber | UJI-B2018-30 | ca_CA |
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