Glutathione-responsive molecular nanoparticles from a dianionic bolaamphiphile and their use as carriers for targeted delivery
Impacte
Scholar |
Altres documents de l'autoria: Navarro Barreda, Diego; Bedrina Broch, Begoña; Galindo, Francisco; Miravet, Juan
Metadades
Mostra el registre complet de l'elementcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/7053
comunitat-uji-handle3:10234/8639
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INVESTIGACIONAquest recurs és restringit
https://doi.org/10.1016/j.jcis.2021.10.142 |
Metadades
Títol
Glutathione-responsive molecular nanoparticles from a dianionic bolaamphiphile and their use as carriers for targeted deliveryData de publicació
2021-11-06Editor
ElsevierISSN
0021-9797Cita bibliogràfica
Navarro-Barreda, D., Bedrina, B., Galindo, F., & Miravet, J. F. (2022). Glutathione-responsive molecular nanoparticles from a dianionic bolaamphiphile and their use as carriers for targeted delivery. Journal of Colloid and Interface Science, 608, 2009-2017.Tipus de document
info:eu-repo/semantics/articleVersió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
The formation in aqueous media of molecular nanoparticles from a bolaamphiphile (SucIleCsa) incorporating a disulfide moiety is described. The particles can be loaded efficiently with the lipophilic mitochondrial ... [+]
The formation in aqueous media of molecular nanoparticles from a bolaamphiphile (SucIleCsa) incorporating a disulfide moiety is described. The particles can be loaded efficiently with the lipophilic mitochondrial marker DiOC6(3), quenching its fluorescence, which is recovered upon reductive particle disassembly. DiOC6(3) transport into human colorectal adenocarcinoma cells (HT-29) is demonstrated using flow cytometry and confocal scanning fluorescence microscopy. A significant increase in intracellular fluorescence is observed when the cells are stimulated to produce glutathione (GSH). These new molecular nanoparticles can be considered a theranostic tool that simultaneously achieves targeted delivery of lipophilic substances and signals high levels of GSH. [-]
Publicat a
ournal of Colloid and Interface Science 608 (2022) 2009–2017Dades relacionades
https://ars.els-cdn.com/content/image/1-s2.0-S0021979721018154-mmc1.docxEntitat finançadora
Ministerio de Ciencia, Innovación y Universidades (Spain) | European Regional Development Fund | FISABIO | Generalitat Valenciana | Universitat Jaume I
Codi del projecte o subvenció
RTI2018-096748-B-I00 | UGP-19-033 | AICO/2020/322 | UJI-B2018-30
Drets d'accés
©2021 Elsevier Inc. All rights reserved.
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/restrictedAccess
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/restrictedAccess
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