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dc.contributor.authorPorru, Simona
dc.contributor.authorMaccioni, Riccardo
dc.contributor.authorBassareo, Valentina
dc.contributor.authorPEANA, Alessandra Tiziana
dc.contributor.authorSalamone, John
dc.date.accessioned2021-03-01T08:44:06Z
dc.date.available2021-03-01T08:44:06Z
dc.date.issued2020-10-24
dc.identifier.citationPORRU, Simona, et al. Effects of caffeine on ethanol-elicited place preference, place aversion and ERK phosphorylation in CD-1 mice. Journal of Psychopharmacology, 2020, vol. 34, no 12, p. 1357-1370.ca_CA
dc.identifier.issn0269-8811
dc.identifier.issn1461-7285
dc.identifier.urihttp://hdl.handle.net/10234/192380
dc.description.abstractBackground: Epidemiological studies indicate a rise in the combined consumption of caffeinated and alcoholic beverages, which can lead to increased risk of alcoholic-beverage overconsumption. However, the effects of the combination of caffeine and ethanol in animal models related to aspects of drug addiction are still underexplored. Aims: To characterize the pharmacological interaction between caffeine and ethanol and establish if caffeine can affect the ability of ethanol (2 g/kg) to elicit conditioned place preference and conditioned place aversion, we administered caffeine (3 or 15 mg/kg) to male CD-1 mice before saline or ethanol. Moreover, we determined if these doses of caffeine could affect ethanol (2 g/kg) elicited extracellular signal-regulated kinase phosphorylation in brain areas, nucleus accumbens, bed nucleus of stria terminalis, central nucleus of the amygdala, and basolateral amygdala, previously associated with this type of associative learning. Results: In the place-conditioning paradigm, caffeine did not have an effect on its own, whereas ethanol elicited significant conditioned-place preference and conditioned-place aversion. Caffeine (15 mg/kg) significantly prevented the acquisition of ethanol-elicited conditioned-place preference and, at both doses, also prevented the acquisition of ethanol-elicited conditioned-place aversion. Moreover, both doses of caffeine also prevented ethanol-elicited extracellular signal-regulated kinase phosphorylation expression in all brain areas examined. Conclusions: The present data indicate a functional antagonistic action of caffeine and ethanol on associative learning and extracellular signal-regulated kinase phosphorylation after an acute interaction. These results could provide exciting grounds for further studies, also in a translational perspective, of their pharmacological interaction modulating other processes involved in drug consumption and addiction.ca_CA
dc.format.extent13 p.ca_CA
dc.language.isoengca_CA
dc.publisherSAGE Publishing
dc.relation.isPartOfJournal of Psychopharmacology.Volume: 34 issue: 12, page(s): 1357-1370ca_CA
dc.rightsCopyright © 2021 by British Association for Psychopharmacologyca_CA
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/*
dc.subjectcaffeineca_CA
dc.subjectconditioned place preferenceca_CA
dc.subjectconditioned place aversionca_CA
dc.subjectethanolca_CA
dc.subjectextended amygdalaca_CA
dc.subjectextracellular signal-regulated kinaseca_CA
dc.titleEffects of caffeine on ethanol-elicited place preference, place aversion and ERK phosphorylation in CD-1 miceca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttps://doi.org/10.1177/0269881120965892
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_CA
dc.relation.publisherVersionhttps://journals.sagepub.com/doi/abs/10.1177/0269881120965892ca_CA
dc.type.versioninfo:eu-repo/semantics/publishedVersionca_CA


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