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Effects of caffeine on ethanol-elicited place preference, place aversion and ERK phosphorylation in CD-1 mice
dc.contributor.author | Porru, Simona | |
dc.contributor.author | Maccioni, Riccardo | |
dc.contributor.author | Bassareo, Valentina | |
dc.contributor.author | PEANA, Alessandra Tiziana | |
dc.contributor.author | Salamone, John | |
dc.date.accessioned | 2021-03-01T08:44:06Z | |
dc.date.available | 2021-03-01T08:44:06Z | |
dc.date.issued | 2020-10-24 | |
dc.identifier.citation | PORRU, Simona, et al. Effects of caffeine on ethanol-elicited place preference, place aversion and ERK phosphorylation in CD-1 mice. Journal of Psychopharmacology, 2020, vol. 34, no 12, p. 1357-1370. | ca_CA |
dc.identifier.issn | 0269-8811 | |
dc.identifier.issn | 1461-7285 | |
dc.identifier.uri | http://hdl.handle.net/10234/192380 | |
dc.description.abstract | Background: Epidemiological studies indicate a rise in the combined consumption of caffeinated and alcoholic beverages, which can lead to increased risk of alcoholic-beverage overconsumption. However, the effects of the combination of caffeine and ethanol in animal models related to aspects of drug addiction are still underexplored. Aims: To characterize the pharmacological interaction between caffeine and ethanol and establish if caffeine can affect the ability of ethanol (2 g/kg) to elicit conditioned place preference and conditioned place aversion, we administered caffeine (3 or 15 mg/kg) to male CD-1 mice before saline or ethanol. Moreover, we determined if these doses of caffeine could affect ethanol (2 g/kg) elicited extracellular signal-regulated kinase phosphorylation in brain areas, nucleus accumbens, bed nucleus of stria terminalis, central nucleus of the amygdala, and basolateral amygdala, previously associated with this type of associative learning. Results: In the place-conditioning paradigm, caffeine did not have an effect on its own, whereas ethanol elicited significant conditioned-place preference and conditioned-place aversion. Caffeine (15 mg/kg) significantly prevented the acquisition of ethanol-elicited conditioned-place preference and, at both doses, also prevented the acquisition of ethanol-elicited conditioned-place aversion. Moreover, both doses of caffeine also prevented ethanol-elicited extracellular signal-regulated kinase phosphorylation expression in all brain areas examined. Conclusions: The present data indicate a functional antagonistic action of caffeine and ethanol on associative learning and extracellular signal-regulated kinase phosphorylation after an acute interaction. These results could provide exciting grounds for further studies, also in a translational perspective, of their pharmacological interaction modulating other processes involved in drug consumption and addiction. | ca_CA |
dc.format.extent | 13 p. | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | SAGE Publishing | |
dc.relation.isPartOf | Journal of Psychopharmacology.Volume: 34 issue: 12, page(s): 1357-1370 | ca_CA |
dc.rights | Copyright © 2021 by British Association for Psychopharmacology | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | * |
dc.subject | caffeine | ca_CA |
dc.subject | conditioned place preference | ca_CA |
dc.subject | conditioned place aversion | ca_CA |
dc.subject | ethanol | ca_CA |
dc.subject | extended amygdala | ca_CA |
dc.subject | extracellular signal-regulated kinase | ca_CA |
dc.title | Effects of caffeine on ethanol-elicited place preference, place aversion and ERK phosphorylation in CD-1 mice | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1177/0269881120965892 | |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | ca_CA |
dc.relation.publisherVersion | https://journals.sagepub.com/doi/abs/10.1177/0269881120965892 | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
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