Effects of caffeine on ethanol-elicited place preference, place aversion and ERK phosphorylation in CD-1 mice
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https://doi.org/10.1177/0269881120965892 |
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Title
Effects of caffeine on ethanol-elicited place preference, place aversion and ERK phosphorylation in CD-1 miceAuthor (s)
Date
2020-10-24Publisher
SAGE PublishingISSN
0269-8811; 1461-7285Bibliographic citation
PORRU, Simona, et al. Effects of caffeine on ethanol-elicited place preference, place aversion and ERK phosphorylation in CD-1 mice. Journal of Psychopharmacology, 2020, vol. 34, no 12, p. 1357-1370.Type
info:eu-repo/semantics/articlePublisher version
https://journals.sagepub.com/doi/abs/10.1177/0269881120965892Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
Background:
Epidemiological studies indicate a rise in the combined consumption of caffeinated and alcoholic beverages, which can lead to increased risk of alcoholic-beverage overconsumption. However, the effects of ... [+]
Background:
Epidemiological studies indicate a rise in the combined consumption of caffeinated and alcoholic beverages, which can lead to increased risk of alcoholic-beverage overconsumption. However, the effects of the combination of caffeine and ethanol in animal models related to aspects of drug addiction are still underexplored.
Aims:
To characterize the pharmacological interaction between caffeine and ethanol and establish if caffeine can affect the ability of ethanol (2 g/kg) to elicit conditioned place preference and conditioned place aversion, we administered caffeine (3 or 15 mg/kg) to male CD-1 mice before saline or ethanol. Moreover, we determined if these doses of caffeine could affect ethanol (2 g/kg) elicited extracellular signal-regulated kinase phosphorylation in brain areas, nucleus accumbens, bed nucleus of stria terminalis, central nucleus of the amygdala, and basolateral amygdala, previously associated with this type of associative learning.
Results:
In the place-conditioning paradigm, caffeine did not have an effect on its own, whereas ethanol elicited significant conditioned-place preference and conditioned-place aversion. Caffeine (15 mg/kg) significantly prevented the acquisition of ethanol-elicited conditioned-place preference and, at both doses, also prevented the acquisition of ethanol-elicited conditioned-place aversion. Moreover, both doses of caffeine also prevented ethanol-elicited extracellular signal-regulated kinase phosphorylation expression in all brain areas examined.
Conclusions:
The present data indicate a functional antagonistic action of caffeine and ethanol on associative learning and extracellular signal-regulated kinase phosphorylation after an acute interaction. These results could provide exciting grounds for further studies, also in a translational perspective, of their pharmacological interaction modulating other processes involved in drug consumption and addiction. [-]
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Journal of Psychopharmacology.Volume: 34 issue: 12, page(s): 1357-1370Rights
Copyright © 2021 by British Association for Psychopharmacology
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