Vitamin D status and latent tuberculosis infection: conversion in nursing homes, Spain
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Other documents of the author: Arnedo-Pena, A.; Juan-Cerdán, J. V.; Romeu-Garcia, M.; Sorribes-Segura, S.; Tirado-Balaguer, M.; GIL FORTUÑO, MARIA; Garcia Ferrer, Daniel; Sabater-Vidal, S.; Iborra-Millet, J.; Vizcaino-Batllés, A.; Meseguer-Ferrer, N.; Vivas-Fornas, I.; Moreno Muñoz, R.; Bellido-Blasco, Juan Bautista
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Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/36080
comunitat-uji-handle3:10234/36082
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https://doi.org/10.5588/ijtld.19.0365 |
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Title
Vitamin D status and latent tuberculosis infection: conversion in nursing homes, SpainAuthor (s)
Date
2020-03-01Publisher
International Union Against Tuberculosis and Lung DiseaseISSN
1027-3719Bibliographic citation
ARNEDO-PENA, A., et al. Vitamin D status and latent tuberculosis infection: conversion in nursing homes, Spain. The International Journal of Tuberculosis and Lung Disease, 2020, vol. 24, no 3, p. 278-286.Type
info:eu-repo/semantics/articlePublisher version
https://www.ingentaconnect.com/content/iuatld/ijtldVersion
info:eu-repo/semantics/publishedVersionSubject
Abstract
OBJECTIVE: To examine the potential association between vitamin D (VitD) deficiency and latent tuberculosis infection (LTBI) and its effect on TB infection conversion (TBIC) incidence.
MATERIAL AND METHODS: We ... [+]
OBJECTIVE: To examine the potential association between vitamin D (VitD) deficiency and latent tuberculosis infection (LTBI) and its effect on TB infection conversion (TBIC) incidence.
MATERIAL AND METHODS: We carried out a cross-sectional and prospective cohort study of nine pulmonary TB cases that occurred in 2015–2016 in five nursing homes and one mental disability institution in Castellon, Spain. QuantiFERON®-TB Gold and the tuberculin skin test were used to detect LTBI and TBIC, respectively. Serum 25-hydroxyvitamin D was measured using chemiluminescence immunoassay. Poisson regression and inverse probability weighting were used for statistical analyses.
RESULTS: The study included 448 residents, 341 staff members with 48 relatives of TB cases (participation rate 82%): of these, respectively 122 (27.2%), 37 (10.9%) and 7 (14.6%) were LTBI-positive; and respectively 22 (7.7%), 10 (3.8%) and 1 (3.7%) were TBIC-positive. LTBI was not associated with VitD status. Severe VitD deficiency (SVDD; defined as VitD level < 10 ng/ml), found in 45.1% of residents, as well as VitD levels of <30 ng/ml (aRR 10.41 95% CI 1.48–73.26), were associated with increased TBIC risk (adjusted relative risk [aRR] 12.1, 95% CI 1.51–97.10), suggesting SVDD as a threshold effect.
CONCLUSION: Severe VitD deficiency is a TBIC risk factor. [-]
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INT J TUBERC LUNG DIS 24(3):278–286Rights
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