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Vitamin D status and latent tuberculosis infection: conversion in nursing homes, Spain
dc.contributor.author | Arnedo-Pena, A. | |
dc.contributor.author | Juan-Cerdán, J. V. | |
dc.contributor.author | Romeu-Garcia, M. | |
dc.contributor.author | Sorribes-Segura, S. | |
dc.contributor.author | Tirado-Balaguer, M. | |
dc.contributor.author | GIL FORTUÑO, MARIA | |
dc.contributor.author | Garcia Ferrer, Daniel | |
dc.contributor.author | Sabater-Vidal, S. | |
dc.contributor.author | Iborra-Millet, J. | |
dc.contributor.author | Vizcaino-Batllés, A. | |
dc.contributor.author | Meseguer-Ferrer, N. | |
dc.contributor.author | Vivas-Fornas, I. | |
dc.contributor.author | Moreno Muñoz, R. | |
dc.contributor.author | Bellido-Blasco, Juan Bautista | |
dc.date.accessioned | 2020-12-15T08:33:15Z | |
dc.date.available | 2020-12-15T08:33:15Z | |
dc.date.issued | 2020-03-01 | |
dc.identifier.citation | ARNEDO-PENA, A., et al. Vitamin D status and latent tuberculosis infection: conversion in nursing homes, Spain. The International Journal of Tuberculosis and Lung Disease, 2020, vol. 24, no 3, p. 278-286. | ca_CA |
dc.identifier.issn | 1027-3719 | |
dc.identifier.uri | http://hdl.handle.net/10234/190898 | |
dc.description.abstract | OBJECTIVE: To examine the potential association between vitamin D (VitD) deficiency and latent tuberculosis infection (LTBI) and its effect on TB infection conversion (TBIC) incidence. MATERIAL AND METHODS: We carried out a cross-sectional and prospective cohort study of nine pulmonary TB cases that occurred in 2015–2016 in five nursing homes and one mental disability institution in Castellon, Spain. QuantiFERON®-TB Gold and the tuberculin skin test were used to detect LTBI and TBIC, respectively. Serum 25-hydroxyvitamin D was measured using chemiluminescence immunoassay. Poisson regression and inverse probability weighting were used for statistical analyses. RESULTS: The study included 448 residents, 341 staff members with 48 relatives of TB cases (participation rate 82%): of these, respectively 122 (27.2%), 37 (10.9%) and 7 (14.6%) were LTBI-positive; and respectively 22 (7.7%), 10 (3.8%) and 1 (3.7%) were TBIC-positive. LTBI was not associated with VitD status. Severe VitD deficiency (SVDD; defined as VitD level < 10 ng/ml), found in 45.1% of residents, as well as VitD levels of <30 ng/ml (aRR 10.41 95% CI 1.48–73.26), were associated with increased TBIC risk (adjusted relative risk [aRR] 12.1, 95% CI 1.51–97.10), suggesting SVDD as a threshold effect. CONCLUSION: Severe VitD deficiency is a TBIC risk factor. | ca_CA |
dc.format.extent | 10 p. | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | International Union Against Tuberculosis and Lung Disease | ca_CA |
dc.relation.isPartOf | INT J TUBERC LUNG DIS 24(3):278–286 | ca_CA |
dc.rights | © 2020 The Union | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | * |
dc.subject | conversion | ca_CA |
dc.subject | infection | ca_CA |
dc.subject | pulmonary | ca_CA |
dc.subject | tuberculosis | ca_CA |
dc.subject | vitamin D | ca_CA |
dc.title | Vitamin D status and latent tuberculosis infection: conversion in nursing homes, Spain | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.5588/ijtld.19.0365 | |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | ca_CA |
dc.relation.publisherVersion | https://www.ingentaconnect.com/content/iuatld/ijtld | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
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