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The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotransposition
dc.contributor.author | Tristán-Ramos, Pablo | |
dc.contributor.author | Rubio Roldán, Alejandro | |
dc.contributor.author | Peris Ripollés, Guillermo | |
dc.contributor.author | Sánchez Contreras, Laura | |
dc.contributor.author | Amador-Cubero, Suyapa | |
dc.contributor.author | Viollet, Sebastien | |
dc.contributor.author | Cristofari, Gael | |
dc.contributor.author | Heras, Sara | |
dc.date.accessioned | 2020-12-10T13:32:28Z | |
dc.date.available | 2020-12-10T13:32:28Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Tristán-Ramos, P., Rubio-Roldan, A., Peris, G. et al. The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotransposition. Nat Commun 11, 5712 (2020). https://doi.org/10.1038/s41467-020-19430-4 | ca_CA |
dc.identifier.issn | 2041-1723 | |
dc.identifier.uri | http://hdl.handle.net/10234/190820 | |
dc.description.abstract | Nearly half of the human genome is made of transposable elements (TEs) whose activity continues to impact its structure and function. Among them, Long INterspersed Element class 1 (LINE-1 or L1) elements are the only autonomously active TEs in humans. L1s are expressed and mobilized in different cancers, generating mutagenic insertions that could affect tumor malignancy. Tumor suppressor microRNAs are ∼22nt RNAs that post-transcriptionally regulate oncogene expression and are frequently downregulated in cancer. Here we explore whether they also influence L1 mobilization. We show that downregulation of let-7 correlates with accumulation of L1 insertions in human lung cancer. Furthermore, we demonstrate that let-7 binds to the L1 mRNA and impairs the translation of the second L1-encoded protein, ORF2p, reducing its mobilization. Overall, our data reveals that let-7, one of the most relevant microRNAs, maintains somatic genome integrity by restricting L1 retrotransposition. | ca_CA |
dc.format.extent | 14 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Nature Research | ca_CA |
dc.relation.isPartOf | Nature Communications volume, 11, 2020. | ca_CA |
dc.rights | This article is licensed under a Creative Commons Attribution 4.0 International License | ca_CA |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-sa/4.0/ | * |
dc.title | The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotransposition | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1038/s41467-020-19430-4 | |
dc.relation.projectID | ERC-2009-StG 243312, Retrogenomics, LABEX SIGNALIFE ANR-11-LABX-0028-01 and IDEX UCAJedi ANR-15-IDEX-01, by CNRS (GDR 3546), MINECO (PEJ-2014-A-31985 and SAF2015-71589-P), SAF2015-71589-P), Ramón y Cajal (RYC-2016-21395) and a Career Integration Grant-Marie Curie (FP7-PEOPLE-2011-CIG-303812). | ca_CA |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | https://www.nature.com/articles/s41467-020-19430-4 | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
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