The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotransposition
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Otros documentos de la autoría: Tristán-Ramos, Pablo; Rubio Roldán, Alejandro; Peris Ripollés, Guillermo; Sánchez Contreras, Laura; Amador-Cubero, Suyapa; Viollet, Sebastien; Cristofari, Gael; Heras, Sara
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INVESTIGACIONMetadatos
Título
The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotranspositionAutoría
Fecha de publicación
2020Editor
Nature ResearchISSN
2041-1723Cita bibliográfica
Tristán-Ramos, P., Rubio-Roldan, A., Peris, G. et al. The tumor suppressor microRNA let-7 inhibits human LINE-1 retrotransposition. Nat Commun 11, 5712 (2020). https://doi.org/10.1038/s41467-020-19430-4Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.nature.com/articles/s41467-020-19430-4Versión
info:eu-repo/semantics/publishedVersionResumen
Nearly half of the human genome is made of transposable elements (TEs) whose activity continues to impact its structure and function. Among them, Long INterspersed Element class 1 (LINE-1 or L1) elements are the only ... [+]
Nearly half of the human genome is made of transposable elements (TEs) whose activity continues to impact its structure and function. Among them, Long INterspersed Element class 1 (LINE-1 or L1) elements are the only autonomously active TEs in humans. L1s are expressed and mobilized in different cancers, generating mutagenic insertions that could affect tumor malignancy. Tumor suppressor microRNAs are ∼22nt RNAs that post-transcriptionally regulate oncogene expression and are frequently downregulated in cancer. Here we explore whether they also influence L1 mobilization. We show that downregulation of let-7 correlates with accumulation of L1 insertions in human lung cancer. Furthermore, we demonstrate that let-7 binds to the L1 mRNA and impairs the translation of the second L1-encoded protein, ORF2p, reducing its mobilization. Overall, our data reveals that let-7, one of the most relevant microRNAs, maintains somatic genome integrity by restricting L1 retrotransposition. [-]
Publicado en
Nature Communications volume, 11, 2020.Proyecto de investigación
ERC-2009-StG 243312, Retrogenomics, LABEX SIGNALIFE ANR-11-LABX-0028-01 and IDEX UCAJedi ANR-15-IDEX-01, by CNRS (GDR 3546), MINECO (PEJ-2014-A-31985 and SAF2015-71589-P), SAF2015-71589-P), Ramón y Cajal (RYC-2016-21395) and a Career Integration Grant-Marie Curie (FP7-PEOPLE-2011-CIG-303812).Derechos de acceso
info:eu-repo/semantics/openAccess
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