Ultra-Performance Liquid Chromatography-Ion Mobility Separation-Quadruple Time-of-Flight MS (UHPLC-IMS-QTOF MS) Metabolomics for Short-Term Biomarker Discovery of Orange Intake: A Randomized, Controlled Crossover Study
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Other documents of the author: Lacalle-Bergeron, Leticia; Portoles, Tania; López, Francisco J.; Sancho, Juan V; CAROLINA, ORTEGA-AZORÍN; Asensio, Eva Maria; Coltell, Oscar; Corella, Dolores
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Title
Ultra-Performance Liquid Chromatography-Ion Mobility Separation-Quadruple Time-of-Flight MS (UHPLC-IMS-QTOF MS) Metabolomics for Short-Term Biomarker Discovery of Orange Intake: A Randomized, Controlled Crossover StudyAuthor (s)
Date
2020Publisher
MDPIISSN
2072-6643Bibliographic citation
Lacalle-Bergeron, L.; Portolés, T.; López, F.J.; Sancho, J.V.; Ortega-Azorín, C.; Asensio, E.M.; Coltell, O.; Corella, D. Ultra-Performance Liquid Chromatography-Ion Mobility Separation-Quadruple Time-of-Flight MS (UHPLC-IMS-QTOF MS) Metabolomics for Short-Term Biomarker Discovery of Orange Intake: A Randomized, Controlled Crossover Study. Nutrients 2020, 12, 1916.Type
info:eu-repo/semantics/articlePublisher version
https://www.mdpi.com/2072-6643/12/7/1916Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
A major problem with dietary assessments is their subjective nature. Untargeted
metabolomics and new technologies can shed light on this issue and provide a more complete
picture of dietary intake by measuring the ... [+]
A major problem with dietary assessments is their subjective nature. Untargeted
metabolomics and new technologies can shed light on this issue and provide a more complete
picture of dietary intake by measuring the profile of metabolites in biological samples. Oranges
are one of the most consumed fruits in the world, and therefore one of the most studied for their
properties. The aim of this work was the application of untargeted metabolomics approach with
the novel combination of ion mobility separation coupled to high resolution mass spectrometry
(IMS-HRMS) and study the advantages that this technique can bring to the area of dietary biomarker
discovery, with the specific case of biomarkers associated with orange consumption (Citrus reticulata)
in plasma samples taken during an acute intervention study (consisting of a randomized, controlled
crossover trial in healthy individuals). A total of six markers of acute orange consumption, including
betonicines and conjugated flavonoids, were identified with the experimental data and previous
literature, demonstrating the advantages of ion mobility in the identification of dietary biomarkers
and the benefits that an additional structural descriptor, as the collision cross section value (CCS), can
provide in this area. [-]
Is part of
Nutrients 2020, 12, 1916Investigation project
UJI 19I001/03, P1–1B2013–54, RYC-2017-22525, CIBER 06/03, SAF2016–80532-R, 538/U/2016, PROMETEO2017/017Rights
info:eu-repo/semantics/openAccess
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