Ultra-Performance Liquid Chromatography-Ion Mobility Separation-Quadruple Time-of-Flight MS (UHPLC-IMS-QTOF MS) Metabolomics for Short-Term Biomarker Discovery of Orange Intake: A Randomized, Controlled Crossover Study
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Otros documentos de la autoría: Lacalle-Bergeron, Leticia; Portoles, Tania; López, Francisco J.; Sancho, Juan V; CAROLINA, ORTEGA-AZORÍN; Asensio, Eva Maria; Coltell, Oscar; Corella, Dolores
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Título
Ultra-Performance Liquid Chromatography-Ion Mobility Separation-Quadruple Time-of-Flight MS (UHPLC-IMS-QTOF MS) Metabolomics for Short-Term Biomarker Discovery of Orange Intake: A Randomized, Controlled Crossover StudyAutoría
Fecha de publicación
2020Editor
MDPIISSN
2072-6643Cita bibliográfica
Lacalle-Bergeron, L.; Portolés, T.; López, F.J.; Sancho, J.V.; Ortega-Azorín, C.; Asensio, E.M.; Coltell, O.; Corella, D. Ultra-Performance Liquid Chromatography-Ion Mobility Separation-Quadruple Time-of-Flight MS (UHPLC-IMS-QTOF MS) Metabolomics for Short-Term Biomarker Discovery of Orange Intake: A Randomized, Controlled Crossover Study. Nutrients 2020, 12, 1916.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.mdpi.com/2072-6643/12/7/1916Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
A major problem with dietary assessments is their subjective nature. Untargeted
metabolomics and new technologies can shed light on this issue and provide a more complete
picture of dietary intake by measuring the ... [+]
A major problem with dietary assessments is their subjective nature. Untargeted
metabolomics and new technologies can shed light on this issue and provide a more complete
picture of dietary intake by measuring the profile of metabolites in biological samples. Oranges
are one of the most consumed fruits in the world, and therefore one of the most studied for their
properties. The aim of this work was the application of untargeted metabolomics approach with
the novel combination of ion mobility separation coupled to high resolution mass spectrometry
(IMS-HRMS) and study the advantages that this technique can bring to the area of dietary biomarker
discovery, with the specific case of biomarkers associated with orange consumption (Citrus reticulata)
in plasma samples taken during an acute intervention study (consisting of a randomized, controlled
crossover trial in healthy individuals). A total of six markers of acute orange consumption, including
betonicines and conjugated flavonoids, were identified with the experimental data and previous
literature, demonstrating the advantages of ion mobility in the identification of dietary biomarkers
and the benefits that an additional structural descriptor, as the collision cross section value (CCS), can
provide in this area. [-]
Publicado en
Nutrients 2020, 12, 1916Proyecto de investigación
UJI 19I001/03, P1–1B2013–54, RYC-2017-22525, CIBER 06/03, SAF2016–80532-R, 538/U/2016, PROMETEO2017/017Derechos de acceso
info:eu-repo/semantics/openAccess
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