Synthesis and biological study of oncoinmunomodulator agents

Abstract

As has been explained in the previous section, numerous therapeutic targets related to the production of proteins such as c-Myc or membrane proteins like PD-L1 and the interaction between them are currently being studied. The aim of this work is to synthesize compounds whose anti-cancer activity is not only capable of slowing the proliferation of tumour cells but also preventing or reducing the interaction of PD-L1 with PD-1 in order to T-cells to recognise malignant cells and cause their death. For all these reasons, the main objectives can be described as: • Synthesis and characterization of anti-cancer agents such as tetrazoles and derivatives, which general structure is represented below in figure 9. . • Biological study of their antiproliferative activity in different cell lines such as lung cancer and colon cancer. • Biological study of the inhibition of the interaction of PD-L1 with PD-1 proteins and their corresponding expression. • Biological study of their behaviour in co-cultures.