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A cross-sectional and longitudinal study on the protective effect of bilingualism against dementia using brain atrophy and cognitive measures.
dc.contributor.author | Costumero, Víctor | |
dc.contributor.author | Marin-Marin, Lidón | |
dc.contributor.author | Calabria, Marco | |
dc.contributor.author | Belloch, Vicente | |
dc.contributor.author | Escudero, Joaquín | |
dc.contributor.author | Baquero Toledo, Miguel | |
dc.contributor.author | Hernández, Mireia | |
dc.contributor.author | Ruiz de Miras, Juan | |
dc.contributor.author | Costa, Albert | |
dc.contributor.author | Parcet, Maria Antonia | |
dc.contributor.author | Avila, Cesar | |
dc.date.accessioned | 2020-01-29T11:45:49Z | |
dc.date.available | 2020-01-29T11:45:49Z | |
dc.date.issued | 2020-01-10 | |
dc.identifier.citation | COSTUMERO, Víctor; MARÍN MARÍN, Lidón; CALABRIA, Marco; BELLOCH, Vicente; ESCUDERO, Joaquín; BAQUERO TOLEDO, Miguel; HERNÁNDEZ, Mireia; RUIZ DE MIRAS, Juan; COSTA MARTÍNEZ, Albert; PARCET, María Antonia; ÁVILA, César (2020). A cross-sectional and longitudinal study on the protective effect of bilingualism against dementia using brain atrophy and cognitive measures. Alzheimer's research & Therapy , v. 12, n. 11 | ca_CA |
dc.identifier.uri | http://hdl.handle.net/10234/186092 | |
dc.description.abstract | Background: Evidence from previous studies suggests that bilingualism contributes to cognitive reserve because bilinguals manifest the first symptoms of Alzheimer’s disease (AD) up to 5 years later than monolinguals. Other cross-sectional studies demonstrate that bilinguals show greater amounts of brain atrophy and hypometabolism than monolinguals, despite sharing the same diagnosis and suffering from the same symptoms. However, these studies may be biased by possible pre-existing between-group differences. Methods: In this study, we used global parenchymal measures of atrophy and cognitive tests to investigate the protective effect of bilingualism against dementia cross-sectionally and prospectively, using a sample of bilinguals and monolinguals in the same clinical stage and matched on sociodemographic variables. Results: Our results suggest that the two groups did not differ in their cognitive status at baseline, but bilinguals had less parenchymal volume than monolinguals, especially in areas related to brain atrophy in dementia. In addition, a longitudinal prospective analysis revealed that monolinguals lost more parenchyma and had more cognitive decline than bilinguals in a mean follow-up period of 7 months. Conclusion: These results provide the first prospective evidence that bilingualism may act as a neuroprotective factor against dementia and could be considered a factor in cognitive reserve. | ca_CA |
dc.format.extent | 10 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Springer | ca_CA |
dc.relation.isPartOf | Alzheimer's Research & Therapy (2020), v. 12, n. 11 | ca_CA |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-sa/4.0/ | * |
dc.subject | Bilingualism | ca_CA |
dc.subject | Cognitive reserve | ca_CA |
dc.subject | Alzheimer’s disease | ca_CA |
dc.subject | Mild cognitive impairment | ca_CA |
dc.subject | Brain atrophy | ca_CA |
dc.subject | Region-based morphometry | ca_CA |
dc.title | A cross-sectional and longitudinal study on the protective effect of bilingualism against dementia using brain atrophy and cognitive measures. | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1186/s13195-020-0581-1 | |
dc.relation.projectID | 1) Project (201410-30-31) provided by Fundació Marató TV3; 2) FPU grant from the Spanish Ministry of Education (FPU17/00698); 3) Juan de la Cierva post-doctoral graduate program grant from the Spanish Ministry of Economy, Industry and Competitiveness (IJCI-2016-29247). | ca_CA |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954576/ | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
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