A cross-sectional and longitudinal study on the protective effect of bilingualism against dementia using brain atrophy and cognitive measures.
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Título
A cross-sectional and longitudinal study on the protective effect of bilingualism against dementia using brain atrophy and cognitive measures.Autoría
Fecha de publicación
2020-01-10Editor
SpringerCita bibliográfica
COSTUMERO, Víctor; MARÍN MARÍN, Lidón; CALABRIA, Marco; BELLOCH, Vicente; ESCUDERO, Joaquín; BAQUERO TOLEDO, Miguel; HERNÁNDEZ, Mireia; RUIZ DE MIRAS, Juan; COSTA MARTÍNEZ, Albert; PARCET, María Antonia; ÁVILA, César (2020). A cross-sectional and longitudinal study on the protective effect of bilingualism against dementia using brain atrophy and cognitive measures. Alzheimer's research & Therapy , v. 12, n. 11Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954576/Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Background: Evidence from previous studies suggests that bilingualism contributes to cognitive reserve because
bilinguals manifest the first symptoms of Alzheimer’s disease (AD) up to 5 years later than monolinguals. ... [+]
Background: Evidence from previous studies suggests that bilingualism contributes to cognitive reserve because
bilinguals manifest the first symptoms of Alzheimer’s disease (AD) up to 5 years later than monolinguals. Other
cross-sectional studies demonstrate that bilinguals show greater amounts of brain atrophy and hypometabolism
than monolinguals, despite sharing the same diagnosis and suffering from the same symptoms. However, these
studies may be biased by possible pre-existing between-group differences.
Methods: In this study, we used global parenchymal measures of atrophy and cognitive tests to investigate the
protective effect of bilingualism against dementia cross-sectionally and prospectively, using a sample of bilinguals
and monolinguals in the same clinical stage and matched on sociodemographic variables.
Results: Our results suggest that the two groups did not differ in their cognitive status at baseline, but bilinguals
had less parenchymal volume than monolinguals, especially in areas related to brain atrophy in dementia. In
addition, a longitudinal prospective analysis revealed that monolinguals lost more parenchyma and had more
cognitive decline than bilinguals in a mean follow-up period of 7 months.
Conclusion: These results provide the first prospective evidence that bilingualism may act as a neuroprotective
factor against dementia and could be considered a factor in cognitive reserve. [-]
Publicado en
Alzheimer's Research & Therapy (2020), v. 12, n. 11Proyecto de investigación
1) Project (201410-30-31) provided by Fundació Marató TV3; 2) FPU grant from the Spanish Ministry of Education (FPU17/00698); 3) Juan de la Cierva post-doctoral graduate program grant from the Spanish Ministry of Economy, Industry and Competitiveness (IJCI-2016-29247).Derechos de acceso
info:eu-repo/semantics/openAccess
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