A cross-sectional and longitudinal study on the protective effect of bilingualism against dementia using brain atrophy and cognitive measures.
![Thumbnail](/xmlui/bitstream/handle/10234/186092/Costumero_2020_Cross.pdf.jpg?sequence=5&isAllowed=y)
View/ Open
Impact
![Google Scholar](/xmlui/themes/Mirage2/images/uji/logo_google.png)
![Microsoft Academico](/xmlui/themes/Mirage2/images/uji/logo_microsoft.png)
Metadata
Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/8033
comunitat-uji-handle3:10234/8636
comunitat-uji-handle4:
INVESTIGACIONMetadata
Title
A cross-sectional and longitudinal study on the protective effect of bilingualism against dementia using brain atrophy and cognitive measures.Author (s)
Date
2020-01-10Publisher
SpringerBibliographic citation
COSTUMERO, Víctor; MARÍN MARÍN, Lidón; CALABRIA, Marco; BELLOCH, Vicente; ESCUDERO, Joaquín; BAQUERO TOLEDO, Miguel; HERNÁNDEZ, Mireia; RUIZ DE MIRAS, Juan; COSTA MARTÍNEZ, Albert; PARCET, María Antonia; ÁVILA, César (2020). A cross-sectional and longitudinal study on the protective effect of bilingualism against dementia using brain atrophy and cognitive measures. Alzheimer's research & Therapy , v. 12, n. 11Type
info:eu-repo/semantics/articlePublisher version
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6954576/Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
Background: Evidence from previous studies suggests that bilingualism contributes to cognitive reserve because
bilinguals manifest the first symptoms of Alzheimer’s disease (AD) up to 5 years later than monolinguals. ... [+]
Background: Evidence from previous studies suggests that bilingualism contributes to cognitive reserve because
bilinguals manifest the first symptoms of Alzheimer’s disease (AD) up to 5 years later than monolinguals. Other
cross-sectional studies demonstrate that bilinguals show greater amounts of brain atrophy and hypometabolism
than monolinguals, despite sharing the same diagnosis and suffering from the same symptoms. However, these
studies may be biased by possible pre-existing between-group differences.
Methods: In this study, we used global parenchymal measures of atrophy and cognitive tests to investigate the
protective effect of bilingualism against dementia cross-sectionally and prospectively, using a sample of bilinguals
and monolinguals in the same clinical stage and matched on sociodemographic variables.
Results: Our results suggest that the two groups did not differ in their cognitive status at baseline, but bilinguals
had less parenchymal volume than monolinguals, especially in areas related to brain atrophy in dementia. In
addition, a longitudinal prospective analysis revealed that monolinguals lost more parenchyma and had more
cognitive decline than bilinguals in a mean follow-up period of 7 months.
Conclusion: These results provide the first prospective evidence that bilingualism may act as a neuroprotective
factor against dementia and could be considered a factor in cognitive reserve. [-]
Is part of
Alzheimer's Research & Therapy (2020), v. 12, n. 11Investigation project
1) Project (201410-30-31) provided by Fundació Marató TV3; 2) FPU grant from the Spanish Ministry of Education (FPU17/00698); 3) Juan de la Cierva post-doctoral graduate program grant from the Spanish Ministry of Economy, Industry and Competitiveness (IJCI-2016-29247).Rights
info:eu-repo/semantics/openAccess
This item appears in the folowing collection(s)
- PSB_Articles [1322]
The following license files are associated with this item: