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Complement proteins regulating macrophage polarisation on biomaterials
dc.contributor.author | Gomes, Nuno | |
dc.contributor.author | Romero-Gavilán, Francisco J | |
dc.contributor.author | Zhang, Yiyue | |
dc.contributor.author | Martinez Ramos, Cristina | |
dc.contributor.author | Elortza, Felix | |
dc.contributor.author | Azkargorta, Mikel | |
dc.contributor.author | Martín de Llano, J. J. | |
dc.contributor.author | GURRUCHAGA, MARILO | |
dc.contributor.author | Goñi, Isabel | |
dc.contributor.author | van den Beucken, J.J.J.P. | |
dc.contributor.author | Suay, Julio | |
dc.date.accessioned | 2019-06-26T07:43:18Z | |
dc.date.available | 2019-06-26T07:43:18Z | |
dc.date.issued | 2019-09-01 | |
dc.identifier.citation | ARAÚJO-GOMES, N., et al. Complement proteins regulating macrophage polarisation on biomaterials. Colloids and Surfaces B: Biointerfaces, 2019, vol. 181, p. 125-133 | ca_CA |
dc.identifier.issn | 0927-7765 | |
dc.identifier.uri | http://hdl.handle.net/10234/182949 | |
dc.description.abstract | One of the events occurring when a biomaterial is implanted in an host is the protein deposition onto its surface, which might regulate cell responses. When a biomaterial displays a compromised biocompatibility, distinct complement pathways can be activated to produce a foreign body reaction. In this article, we have designed different types of biomaterial surfaces to study the inflammation process. Here, we used different concentrations of (3-glycidoxypropyl)-trimethoxysilane (GPTMS), an organically-modified alkoxysilane as a precursor for the synthesis of various types of sol-gel materials functionalizing coatings for titanium implants to regulate biological responses. Our results showed that greater GPTMS surface concentrations induced greater secretion of TNF-α and IL-10 on RAW 264.7 macrophages. When implanted into rabbit tibia, osseointegration decreased with higher GPTMS concentrations. Interestingly, higher deposition of complement-related proteins C-reactive protein (CRP) and ficolin-2 (FCN2), two main activators of distinct complement pathways, was observed. Taking all together, inflammatory potential increase seems to be GPTMS concentration-dependent. Our results show that a greater adsorption of complement proteins can condition macrophage polarization. | ca_CA |
dc.format.extent | 9 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Elsevier | ca_CA |
dc.relation.isPartOf | Colloids and Surfaces B: Biointerfaces, 2019, vol. 181 | ca_CA |
dc.rights | © Elsevier B.V. | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | * |
dc.subject | complement system | ca_CA |
dc.subject | immune response | ca_CA |
dc.subject | proteomics | ca_CA |
dc.subject | dental implants | ca_CA |
dc.subject | hybrid sol-gel | ca_CA |
dc.subject | macrophage plasticity | ca_CA |
dc.title | Complement proteins regulating macrophage polarisation on biomaterials | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1016/j.colsurfb.2019.05.039 | |
dc.relation.projectID | MINECO: MAT2017-86043-R]; Universitat Jaume I: Predoc/2014/25, UJI-B2017-37; Basque Government : IT611-13, Predoc/2016/1/0141]; University of the Basque Country [UFI11/56]; CIC bioGUNE is supported by Basque Department of Industry, Tourism and Trade (Etortek and Elkartek programs), ProteoRed-ISCIII: PRB3 IPT17/0019; CIBERehd Network; Severo Ochoa Grant: SEV-2016-0644] | ca_CA |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | https://www.sciencedirect.com/science/article/pii/S0927776519303479?via%3Dihub#! | ca_CA |
dc.type.version | info:eu-repo/semantics/submittedVersion | ca_CA |
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