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dc.contributor.authorGomes, Nuno
dc.contributor.authorRomero-Gavilán, Francisco J
dc.contributor.authorZhang, Yiyue
dc.contributor.authorMartinez Ramos, Cristina
dc.contributor.authorElortza, Felix
dc.contributor.authorAzkargorta, Mikel
dc.contributor.authorMartín de Llano, J. J.
dc.contributor.authorGURRUCHAGA, MARILO
dc.contributor.authorGoñi, Isabel
dc.contributor.authorvan den Beucken, J.J.J.P.
dc.contributor.authorSuay, Julio
dc.date.accessioned2019-06-26T07:43:18Z
dc.date.available2019-06-26T07:43:18Z
dc.date.issued2019-09-01
dc.identifier.citationARAÚJO-GOMES, N., et al. Complement proteins regulating macrophage polarisation on biomaterials. Colloids and Surfaces B: Biointerfaces, 2019, vol. 181, p. 125-133ca_CA
dc.identifier.issn0927-7765
dc.identifier.urihttp://hdl.handle.net/10234/182949
dc.description.abstractOne of the events occurring when a biomaterial is implanted in an host is the protein deposition onto its surface, which might regulate cell responses. When a biomaterial displays a compromised biocompatibility, distinct complement pathways can be activated to produce a foreign body reaction. In this article, we have designed different types of biomaterial surfaces to study the inflammation process. Here, we used different concentrations of (3-glycidoxypropyl)-trimethoxysilane (GPTMS), an organically-modified alkoxysilane as a precursor for the synthesis of various types of sol-gel materials functionalizing coatings for titanium implants to regulate biological responses. Our results showed that greater GPTMS surface concentrations induced greater secretion of TNF-α and IL-10 on RAW 264.7 macrophages. When implanted into rabbit tibia, osseointegration decreased with higher GPTMS concentrations. Interestingly, higher deposition of complement-related proteins C-reactive protein (CRP) and ficolin-2 (FCN2), two main activators of distinct complement pathways, was observed. Taking all together, inflammatory potential increase seems to be GPTMS concentration-dependent. Our results show that a greater adsorption of complement proteins can condition macrophage polarization.ca_CA
dc.format.extent9 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherElsevierca_CA
dc.relation.isPartOfColloids and Surfaces B: Biointerfaces, 2019, vol. 181ca_CA
dc.rights© Elsevier B.V.ca_CA
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/*
dc.subjectcomplement systemca_CA
dc.subjectimmune responseca_CA
dc.subjectproteomicsca_CA
dc.subjectdental implantsca_CA
dc.subjecthybrid sol-gelca_CA
dc.subjectmacrophage plasticityca_CA
dc.titleComplement proteins regulating macrophage polarisation on biomaterialsca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttps://doi.org/10.1016/j.colsurfb.2019.05.039
dc.relation.projectIDMINECO: MAT2017-86043-R]; Universitat Jaume I: Predoc/2014/25, UJI-B2017-37; Basque Government : IT611-13, Predoc/2016/1/0141]; University of the Basque Country [UFI11/56]; CIC bioGUNE is supported by Basque Department of Industry, Tourism and Trade (Etortek and Elkartek programs), ProteoRed-ISCIII: PRB3 IPT17/0019; CIBERehd Network; Severo Ochoa Grant: SEV-2016-0644]ca_CA
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_CA
dc.relation.publisherVersionhttps://www.sciencedirect.com/science/article/pii/S0927776519303479?via%3Dihub#!ca_CA
dc.type.versioninfo:eu-repo/semantics/submittedVersionca_CA


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