Synthesis and biological evaluation of anticancer compounds
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Synthesis and biological evaluation of anticancer compoundsAutoria
Tutor/Supervisor; Universitat.Departament
Carda Usó, Pedro Miguel; Universitat Jaume I. Departament de Química Inorgànica i OrgànicaData de publicació
2018-07Editor
Universitat Jaume IResum
Imidazole is an important nucleus that can be found in Nature and it is present in
many biomolecules. Compounds including an imidazole are used as new drugs in
medicinal chemistry, including anti-cancer reagents. ... [+]
Imidazole is an important nucleus that can be found in Nature and it is present in
many biomolecules. Compounds including an imidazole are used as new drugs in
medicinal chemistry, including anti-cancer reagents. However, there is still the need to
improve of already used drugs and the search for new and more effective drugs. Thus,
the aims of the current study are twofold, by one hand the synthesis of 1-benzyl-4-
phenyl-1H-imidazole and derivatives and by the other hand their biological evaluation as
c-MYC gene and PD-L1 inhibitors.
The more specific objectives of this study were:
1. The synthesis of 1-arylmethyl-4-fenil-1H-imidazoles whose general structure is
shown in the following figure.
2. The biological evaluation of the above mentioned compounds as regards:
• Their antiproliferative activity.
• Their interaction with PD-L1 protein.
• Their activity on the inhibition of c-MYC gene and PD-L1 protein. [-]
Paraules clau / Matèries
Descripció
Treball Final de Grau en Química. Codi: QU0943. Curs acadèmic: 2017/2018
Tipus de document
info:eu-repo/semantics/bachelorThesisDrets d'accés
http://rightsstatements.org/vocab/CNE/1.0/
info:eu-repo/semantics/restrictedAccess
info:eu-repo/semantics/restrictedAccess
Apareix a les col.leccions
- Grau en Química [265]