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Synthesis and biological evaluation of anticancer compounds
dc.contributor.author | Llanos Gargallo, Ana | |
dc.contributor.other | Carda Usó, Pedro Miguel | |
dc.contributor.other | Universitat Jaume I. Departament de Química Inorgànica i Orgànica | |
dc.date.accessioned | 2018-10-02T10:32:58Z | |
dc.date.available | 2018-10-02T10:32:58Z | |
dc.date.issued | 2018-07 | |
dc.identifier.uri | http://hdl.handle.net/10234/176456 | |
dc.description | Treball Final de Grau en Química. Codi: QU0943. Curs acadèmic: 2017/2018 | ca_CA |
dc.description.abstract | Imidazole is an important nucleus that can be found in Nature and it is present in many biomolecules. Compounds including an imidazole are used as new drugs in medicinal chemistry, including anti-cancer reagents. However, there is still the need to improve of already used drugs and the search for new and more effective drugs. Thus, the aims of the current study are twofold, by one hand the synthesis of 1-benzyl-4- phenyl-1H-imidazole and derivatives and by the other hand their biological evaluation as c-MYC gene and PD-L1 inhibitors. The more specific objectives of this study were: 1. The synthesis of 1-arylmethyl-4-fenil-1H-imidazoles whose general structure is shown in the following figure. 2. The biological evaluation of the above mentioned compounds as regards: • Their antiproliferative activity. • Their interaction with PD-L1 protein. • Their activity on the inhibition of c-MYC gene and PD-L1 protein. | ca_CA |
dc.format.extent | 73 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Universitat Jaume I | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/CNE/1.0/ | * |
dc.subject | Grau en Química | ca_CA |
dc.subject | Grado en Química | ca_CA |
dc.subject | Bachelor's Degree in Chemistry | ca_CA |
dc.title | Synthesis and biological evaluation of anticancer compounds | ca_CA |
dc.type | info:eu-repo/semantics/bachelorThesis | ca_CA |
dc.educationLevel | Estudios de Grado | ca_CA |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | ca_CA |
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Grau en Química [265]
QU0943