Synthesis, acid-base properties and hydrogel formation studies of a bisquinoline based low molecular weight gelator
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Mostra el registre complet de l'elementcomunitat-uji-handle:10234/158176
comunitat-uji-handle2:10234/71324
comunitat-uji-handle3:10234/98504
comunitat-uji-handle4:
TFG-TFMMetadades
Títol
Synthesis, acid-base properties and hydrogel formation studies of a bisquinoline based low molecular weight gelatorAutoria
Tutor/Supervisor; Universitat.Departament
Miravet Celades, Juan Felipe; Universitat Jaume I. Departament de Química Inorgànica i OrgànicaData de publicació
2018-07Editor
Universitat Jaume IResum
The research group, where this final degree project was carried out, was
interested in the use of molecule QVal3 (see structure below) as a hydrogelator
which could be used for entrapment and release of bioactive ... [+]
The research group, where this final degree project was carried out, was
interested in the use of molecule QVal3 (see structure below) as a hydrogelator
which could be used for entrapment and release of bioactive substances and for
the preparation of nano/microparticles. This compound is related to previouslyl
reported structures prepared in the group. As a first step towards that goal, this
project aims to optimize the synthetic preparation of QVal3 and study its hydrogel
formation properties.12, 13
In detail the objectives are the following:
i. The synthesis and characterization of QVal3. In particular, optimization of
the amide formation step implied in its preparation.
ii. Determination of the minimum gelator concentration in aqueous media
and evaluation of the influence of the concentration of DMSO present, in
a small proportion due to gel preparation procedure, on the gelation
efficiency.
iii. Evaluation of the acid-base constants of QVal3 to assess the range of pH
where the molecule is neutral and prone to aggregation. Likewise, the
influence of different amounts of DMSO in the aqueous system on pKa
values will be tested. [-]
Paraules clau / Matèries
Descripció
Treball Final de Grau en Química. Codi: QU0943. Curs acadèmic: 2017/2018
Tipus de document
info:eu-repo/semantics/bachelorThesisDrets d'accés
info:eu-repo/semantics/openAccess
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- Grau en Química [265]
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